Shaoyou Chu, MD, PhD

Key Publications

1: Jesudason CD, Rangel-Barajas C, Beach CJ, Beck DE, Caballero-Floran IH,

Clayton WB, Da Silva L, David JC, Doolen S, Faulkner AN, Hamdani AK, Huhe H,

Huynh K, Imhoff RD, Javens-Wolfe J, Mason ER, Moussaif M, Singhal K, Soni DM,

van Buuren-Milne M, Williams SP, Angus SP, Chu S, Dage JL, Hipskind PA, Johnson

TS, Kaddurah-Daouk R, Lamb BT, Meikle PJ, Mesecar AD, Palkowitz AD, Quinney SK,

Sukoff Rizzo SJ, Oblak AL, Richardson TI. Optimization and Characterization of

SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease

Models. J Med Chem. 2026 May 14;69(9):10734-10763. doi:

10.1021/acs.jmedchem.6c00010. Epub 2026 Apr 30. PMID: 42059452.

2: Weerawarna PM, Jesudason CD, Lobb KL, Mason ER, Gu X, Chu S, Richardson TI.

Curated set of tool compounds to probe PYK2 and FAK signaling in Alzheimer's

disease. Alzheimers Dement. 2026 May;22(5):e71508. doi: 10.1002/alz.71508. PMID:

42210035; PMCID: PMC13239879.

3: Rogers LM, Firestone K, Chinni R, Branco AC, Wrobleski K, Chou T, Goldstein

JA, Gu X, Mason E, Chu S, der Lohe MR, Low P, Aronoff DM. Folate receptor beta

drives NLRP3 inflammasome activation and pyroptosis in macrophages independent

of folate binding. J Immunol. 2026 Apr 15;215(4):vkag051. doi:

10.1093/jimmun/vkag051. PMID: 41984502.

4: Haskell AK, Kulas JA, Carter WE, Javens-Wolfe J, Hinkel RD, Moussaif M,

Smiley JS, Lazaro O, Robertson S, Palkowitz AD, Lamb BT, Richardson TI, Dage JL,

Chu S, Johnson T, Stancato LF, Syed AQ. Generation and characterization of iPSC-

derived microglia for in vitro modeling of stimuli-specific neuroimmune

responses. Alzheimers Dement. 2026 Feb;22(2):e71117. doi: 10.1002/alz.71117.

PMID: 41639038; PMCID: PMC12872402.

5: Jesudason CD, Rangel-Barajas C, Beach CJ, Beck DE, Caballero-Floran IH,

Clayton WB, Da Silva L, David JC, Doolen S, Faulkner AN, Hamdani AK, Huhe H,

Huynh K, Imhoff RD, Javens-Wolfe J, Mason ER, Moussaif M, Singhal K, Soni DM,

van Buuren-Milne M, Williams SP, Angus SP, Chu S, Dage JL, Hipskind PA, Johnson

TS, Kaddurah-Daouk R, Lamb BT, Meikle PJ, Mesecar AD, Palkowitz AD, Quinney SK,

Sukoff Rizzo SJ, Oblak AL, Richardson TI. Optimization and Characterization of

SHIP1 Ligands for Cellular Target Engagement and Activity in Alzheimer's Disease

Models. bioRxiv [Preprint]. 2026 Jan 2:2025.12.31.697127. doi:

10.64898/2025.12.31.697127. Update in: J Med Chem. 2026 May

14;69(9):10734-10763. doi: 10.1021/acs.jmedchem.6c00010. PMID: 41509252; PMCID:

PMC12776292.

6: Miao J, Lin J, Dong J, Amarasinghe O, Mason ER, Chu S, Qu Z, Cullers CC, Putt

KS, Zhang ZY. Discovery and evaluation of novel SHIP-1 inhibitors. Bioorg Med

Chem. 2024 Nov 15;114:117965. doi: 10.1016/j.bmc.2024.117965. Epub 2024 Oct 19.

PMID: 39454561; PMCID: PMC11551725.

7: Soni DM, Lin PB, Lee-Gosselin A, Lloyd CD, Mason E, Ingraham CM, Perkins A,

Moutinho M, Lamb BT, Chu S, Oblak AL. Inpp5d haplodeficiency alleviates tau

pathology in the PS19 mouse model of Tauopathy. Alzheimers Dement. 2024

Jul;20(7):4985-4998. doi: 10.1002/alz.14078. Epub 2024 Jun 26. PMID: 38923171;

PMCID: PMC11247686.

8: Ahat E, Shi Z, Chu S, Bui HH, Mason ER, Soni DM, Roth KD, Chalmers MJ, Oblak

AL, Zhang J, Gutierrez JA, Richardson T. SHIP1 modulation and proteome

characterization of microglia. J Proteomics. 2024 Jun 30;302:105198. doi:

10.1016/j.jprot.2024.105198. Epub 2024 May 20. PMID: 38777089; PMCID:

PMC12503353.

9: Atomwise AIMS Program. AI is a viable alternative to high throughput

screening: a 318-target study. Sci Rep. 2024 Apr 2;14(1):7526. doi:

10.1038/s41598-024-54655-z. Erratum in: Sci Rep. 2024 Sep 16;14(1):21579. doi:

10.1038/s41598-024-70321-w. PMID: 38565852; PMCID: PMC10987645.

10: Jesudason CD, Mason ER, Chu S, Oblak AL, Javens-Wolfe J, Moussaif M, Durst

G, Hipskind P, Beck DE, Dong J, Amarasinghe O, Zhang ZY, Hamdani AK, Singhal K,

Mesecar AD, Souza S, Jacobson M, Salvo JD, Soni DM, Kandasamy M, Masters AR,

Quinney SK, Doolen S, Huhe H, Rizzo SJS, Lamb BT, Palkowitz AD, Richardson TI.

SHIP1 therapeutic target enablement: Identification and evaluation of inhibitors

for the treatment of late-onset Alzheimer's disease. Alzheimers Dement (N Y).

2023 Nov 17;9(4):e12429. doi: 10.1002/trc2.12429. PMID: 38023622; PMCID:

PMC10655782.

11: Mason ER, Soni DM, Chu S. Microglial Phagocytosis/Cell Health High-Content

Assay. Curr Protoc. 2023 Mar;3(3):e724. doi: 10.1002/cpz1.724. Erratum in: Curr

Protoc. 2023 Apr;3(4):e773. doi: 10.1002/cpz1.773. PMID: 36971657; PMCID:

PMC10433541.

12: Potjewyd FM, Annor-Gyamfi JK, Aubé J, Chu S, Conlon IL, Frankowski KJ,

Guduru SKR, Hardy BP, Hopkins MD, Kinoshita C, Kireev DB, Mason ER, Moerk CT,

Nwogbo F, Pearce KH, Richardson TI, Rogers DA, Soni DM, Stashko M, Wang X, Wells

C, Willson TM, Frye SV, Young JE, Axtman AD. AD Informer Set: Chemical tools to

facilitate Alzheimer's disease drug discovery. Alzheimers Dement (N Y). 2022 Apr

20;8(1):e12246. doi: 10.1002/trc2.12246. PMID: 35475262; PMCID: PMC9019904.

13: Potjewyd FM, Annor-Gyamfi JK, Aubé J, Chu S, Conlon IL, Frankowski KJ,

Guduru SKR, Hardy BP, Hopkins MD, Kinoshita C, Kireev DB, Mason ER, Moerk CT,

Nwogbo F, Pearce KH Jr, Richardson TI, Rogers DA, Soni DM, Stashko M, Wang X,

Wells C, Willson TM, Frye SV, Young JE, Axtman AD. Use of AD Informer Set

compounds to explore validity of novel targets in Alzheimer's disease pathology.

Alzheimers Dement (N Y). 2022 Apr 12;8(1):e12253. doi: 10.1002/trc2.12253. PMID:

35434254; PMCID: PMC9005681.

14: Karahan H, Smith DC, Kim B, Dabin LC, Al-Amin MM, Wijeratne HRS, Pennington

T, Viana di Prisco G, McCord B, Lin PB, Li Y, Peng J, Oblak AL, Chu S, Atwood

BK, Kim J. Deletion of Abi3 gene locus exacerbates neuropathological

features of Alzheimer's disease in a mouse model of Aβ amyloidosis. Sci Adv.

2021 Nov 5;7(45):eabe3954. doi: 10.1126/sciadv.abe3954. Epub 2021 Nov 3. PMID:

34731000; PMCID: PMC8565913.

15: Du J, Yan L, Torres R, Gong X, Bian H, Marugán C, Boehnke K, Baquero C, Hui

YH, Chapman SC, Yang Y, Zeng Y, Bogner SM, Foreman RT, Capen A, Donoho GP, Van

Horn RD, Barnard DS, Dempsey JA, Beckmann RP, Marshall MS, Chio LC, Qian Y,

Webster YW, Aggarwal A, Chu S, Bhattachar S, Stancato LF, Dowless MS, Iversen

PW, Manro JR, Walgren JL, Halstead BW, Dieter MZ, Martinez R, Bhagwat SV,

Kreklau EL, Lallena MJ, Ye XS, Patel BKR, Reinhard C, Plowman GD, Barda DA,

Henry JR, Buchanan SG, Campbell RM. Aurora A-Selective Inhibitor LY3295668 Leads

to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent

Preclinical Antitumor Efficacy. Mol Cancer Ther. 2019 Dec;18(12):2207-2219. doi:

10.1158/1535-7163.MCT-18-0529. Epub 2019 Sep 17. PMID: 31530649.

16: Sarmah S, Curtis C, Mahin J, Farrell M, Engler TA, Sanchez-Felix MV, Sato M,

Ma YL, Chu S, Marrs JA. The Glycogen Synthase Kinase-3β Inhibitor LSN 2105786

Promotes Zebrafish Fin Regeneration. Biomedicines. 2019 Apr 19;7(2):30. doi:

10.3390/biomedicines7020030. PMID: 31010223; PMCID: PMC6630808.

17: Gong X, Du J, Parsons SH, Merzoug FF, Webster Y, Iversen PW, Chio LC, Van

Horn RD, Lin X, Blosser W, Han B, Jin S, Yao S, Bian H, Ficklin C, Fan L, Kapoor

A, Antonysamy S, Mc Nulty AM, Froning K, Manglicmot D, Pustilnik A, Weichert K,

Wasserman SR, Dowless M, Marugán C, Baquero C, Lallena MJ, Eastman SW, Hui YH,

Dieter MZ, Doman T, Chu S, Qian HR, Ye XS, Barda DA, Plowman GD, Reinhard C,

Campbell RM, Henry JR, Buchanan SG. Aurora A Kinase Inhibition Is Synthetic

Lethal with Loss of the RB1 Tumor Suppressor Gene. Cancer Discov. 2019

Feb;9(2):248-263. doi: 10.1158/2159-8290.CD-18-0469. Epub 2018 Oct 29. PMID:

30373917.

18: Krishnan V, Ma YL, Chen CZ, Thorne N, Bullock H, Tawa G, Javella-Cauley C,

Chu S, Li W, Kohn W, Adrian MD, Benson C, Liu L, Sato M, Zheng W, Pilon AM, Yang

NN, Bryant HU. Repurposing a novel parathyroid hormone analogue to treat

hypoparathyroidism. Br J Pharmacol. 2018 Jan;175(2):262-271. doi:

10.1111/bph.14028. Epub 2017 Nov 28. PMID: 28898923; PMCID: PMC5758387.

19: Gong X, Litchfield LM, Webster Y, Chio LC, Wong SS, Stewart TR, Dowless M,

Dempsey J, Zeng Y, Torres R, Boehnke K, Mur C, Marugán C, Baquero C, Yu C, Bray

SM, Wulur IH, Bi C, Chu S, Qian HR, Iversen PW, Merzoug FF, Ye XS, Reinhard C,

De Dios A, Du J, Caldwell CW, Lallena MJ, Beckmann RP, Buchanan SG. Genomic

Aberrations that Activate D-type Cyclins Are Associated with Enhanced

Sensitivity to the CDK4 and CDK6 Inhibitor Abemaciclib. Cancer Cell. 2017 Dec

11;32(6):761-776.e6. doi: 10.1016/j.ccell.2017.11.006. PMID: 29232554.

20: Peng SB, Zhang X, Paul D, Kays LM, Ye M, Vaillancourt P, Dowless M, Stancato

LF, Stewart J, Uhlik MT, Long H, Chu S, Obungu VH. Inhibition of CXCR4 by

LY2624587, a Fully Humanized Anti-CXCR4 Antibody Induces Apoptosis of

Hematologic Malignancies. PLoS One. 2016 Mar 8;11(3):e0150585. doi:

10.1371/journal.pone.0150585. PMID: 26954567; PMCID: PMC4782998.

21: Lee JA, Shinn P, Jaken S, Oliver S, Willard FS, Heidler S, Peery RB, Oler J,

Chu S, Southall N, Dexheimer TS, Smallwood J, Huang R, Guha R, Jadhav A, Cox K,

Austin CP, Simeonov A, Sittampalam GS, Husain S, Franklin N, Wild DJ, Yang JJ,

Sutherland JJ, Thomas CJ. Novel Phenotypic Outcomes Identified for a Public

Collection of Approved Drugs from a Publicly Accessible Panel of Assays. PLoS

One. 2015 Jul 15;10(7):e0130796. doi: 10.1371/journal.pone.0130796. PMID:

26177200; PMCID: PMC4503722.

22: Beidler CB, Petrovan RJ, Conner EM, Boyles JS, Yang DD, Harlan SM, Chu S,

Ellis B, Datta-Mannan A, Johnson RL, Stauber A, Witcher DR, Breyer MD, Heuer JG.

Generation and activity of a humanized monoclonal antibody that selectively

neutralizes the epidermal growth factor receptor ligands transforming growth

factor-α and epiregulin. J Pharmacol Exp Ther. 2014 May;349(2):330-43. doi:

10.1124/jpet.113.210765. Epub 2014 Feb 11. PMID: 24518034.

23: Torres-Guzmán R, Chu S, Velasco JA, Lallena MJ. Multiparametric cell-based

assay for the evaluation of transcription inhibition by high-content imaging. J

Biomol Screen. 2013 Jun;18(5):556-66. doi: 10.1177/1087057112472539. Epub 2013

Jan 10. PMID: 23307837.

24: Lee JA, Chu S, Willard FS, Cox KL, Sells Galvin RJ, Peery RB, Oliver SE,

Oler J, Meredith TD, Heidler SA, Gough WH, Husain S, Palkowitz AD, Moxham CM.

Open innovation for phenotypic drug discovery: The PD2 assay panel. J Biomol

Screen. 2011 Jul;16(6):588-602. doi: 10.1177/1087057111405379. Epub 2011 Apr 26.

PMID: 21521801.

25: Van Horn RD, Chu S, Fan L, Yin T, Du J, Beckmann R, Mader M, Zhu G, Toth J,

Blanchard K, Ye XS. Cdk1 activity is required for mitotic activation of aurora A

during G2/M transition of human cells. J Biol Chem. 2010 Jul 9;285(28):21849-57.

doi: 10.1074/jbc.M110.141010. Epub 2010 May 5. PMID: 20444701; PMCID:

PMC2898447.

26: Shen F, Bailey BJ, Chu S, Bence AK, Xue X, Erickson P, Safa AR, Beck WT,

Erickson LC. Dynamic assessment of mitoxantrone resistance and modulation of

multidrug resistance by valspodar (PSC833) in multidrug resistance human cancer

cells. J Pharmacol Exp Ther. 2009 Aug;330(2):423-9. doi:

10.1124/jpet.109.153551. Epub 2009 May 7. PMID: 19423841; PMCID: PMC2713081.

27: Zhao J, Evans G, Li W, Green L, Chu S, Marder P, Na S. Rapid and

quantitative detection of p38 kinase pathway in mouse blood monocyte. In Vitro

Cell Dev Biol Anim. 2008 May-Jun;44(5-6):145-53. doi: 10.1007/s11626-008-9088-y.

Epub 2008 Apr 9. PMID: 18398666.

28: Chen YQ, Kuo MS, Li S, Bui HH, Peake DA, Sanders PE, Thibodeaux SJ, Chu S,

Qian YW, Zhao Y, Bredt DS, Moller DE, Konrad RJ, Beigneux AP, Young SG, Cao G.

AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. J Biol Chem.

2008 Apr 11;283(15):10048-57. doi: 10.1074/jbc.M708151200. Epub 2008 Jan 31.

PMID: 18238778; PMCID: PMC2442282.

29: Shen F, Chu S, Bence AK, Bailey B, Xue X, Erickson PA, Montrose MH, Beck WT,

Erickson LC. Quantitation of doxorubicin uptake, efflux, and modulation of

multidrug resistance (MDR) in MDR human cancer cells. J Pharmacol Exp Ther. 2008

Jan;324(1):95-102. doi: 10.1124/jpet.107.127704. Epub 2007 Oct 18. PMID:

17947497.

30: Qian YW, Schmidt RJ, Zhang Y, Chu S, Lin A, Wang H, Wang X, Beyer TP, Bensch

WR, Li W, Ehsani ME, Lu D, Konrad RJ, Eacho PI, Moller DE, Karathanasis SK, Cao

G. Secreted PCSK9 downregulates low density lipoprotein receptor through

receptor-mediated endocytosis. J Lipid Res. 2007 Jul;48(7):1488-98. doi:

10.1194/jlr.M700071-JLR200. Epub 2007 Apr 20. PMID: 17449864.

31: Gens JS, Du H, Tackett L, Kong SS, Chu S, Montrose MH. Different ionic

conditions prompt NHE2 and NHE3 translocation to the plasma membrane. Biochim

Biophys Acta. 2007 May;1768(5):1023-35. doi: 10.1016/j.bbamem.2007.01.003. Epub

2007 Jan 12. PMID: 17303069; PMCID: PMC1974857.

32: Sours S, Du J, Chu S, Ding M, Zhou XJ, Ma R. Expression of canonical

transient receptor potential (TRPC) proteins in human glomerular mesangial

cells. Am J Physiol Renal Physiol. 2006 Jun;290(6):F1507-15. doi:

10.1152/ajprenal.00268.2005. Epub 2006 Jan 17. PMID: 16418302.

33: Watson AJ, Chu S, Sieck L, Gerasimenko O, Bullen T, Campbell F, McKenna M,

Rose T, Montrose MH. Epithelial barrier function in vivo is sustained despite

gaps in epithelial layers. Gastroenterology. 2005 Sep;129(3):902-12. doi:

10.1053/j.gastro.2005.06.015. PMID: 16143130.

34: Lammers PE, Beck JA, Chu S, Kempson SA. Hypertonic upregulation of betaine

transport in renal cells is blocked by a proteasome inhibitor. Cell Biochem

Funct. 2005 Sep-Oct;23(5):315-24. doi: 10.1002/cbf.1241. PMID: 15945068.

35: Cammarata PR, Flynn J, Gottipati S, Chu S, Dimitrijevich S, Younes M,

Skliris G, Murphy LC. Differential expression and comparative subcellular

localization of estrogen receptor beta isoforms in virally transformed and

normal cultured human lens epithelial cells. Exp Eye Res. 2005 Aug;81(2):165-75.

doi: 10.1016/j.exer.2005.01.019. PMID: 16080910.

36: Chu S, Bohlen HG. High concentration of glucose inhibits glomerular

endothelial eNOS through a PKC mechanism. Am J Physiol Renal Physiol. 2004

Sep;287(3):F384-92. doi: 10.1152/ajprenal.00006.2004. Epub 2004 May 12. PMID:

15140758.

37: Cammarata PR, Chu S, Moor A, Wang Z, Yang SH, Simpkins JW. Subcellular

distribution of native estrogen receptor alpha and beta subtypes in cultured

human lens epithelial cells. Exp Eye Res. 2004 Apr;78(4):861-71. doi:

10.1016/j.exer.2003.09.027. PMID: 15037120.

38: Kempson SA, Parikh V, Xi L, Chu S, Montrose MH. Subcellular redistribution

of the renal betaine transporter during hypertonic stress. Am J Physiol Cell

Physiol. 2003 Nov;285(5):C1091-100. doi: 10.1152/ajpcell.00021.2003. Epub 2003

Jul 2. PMID: 12839828.

39: Bricker JL, Chu S, Kempson SA. Disruption of F-actin stimulates hypertonic

activation of the BGT1 transporter in MDCK cells. Am J Physiol Renal Physiol.

2003 May;284(5):F930-7. doi: 10.1152/ajprenal.00289.2002. Epub 2003 Jan 14.

PMID: 12527556.

40: Hanson GT, McAnaney TB, Park ES, Rendell ME, Yarbrough DK, Chu S, Xi L,

Boxer SG, Montrose MH, Remington SJ. Green fluorescent protein variants as

ratiometric dual emission pH sensors. 1. Structural characterization and

preliminary application. Biochemistry. 2002 Dec 31;41(52):15477-88. doi:

10.1021/bi026609p. PMID: 12501176.

41: Baumgartner HK, Kirbiyik U, Coskun T, Chu S, Montrose MH. Endogenous cyclo-

oxygenase activity regulates mouse gastric surface pH. J Physiol. 2002 Nov

1;544(3):871-82. doi: 10.1113/jphysiol.2002.024620. PMID: 12411530; PMCID:

PMC2290623.

42: Coskun T, Baumgartner HK, Chu S, Montrose MH. Coordinated regulation of

gastric chloride secretion with both acid and alkali secretion. Am J Physiol

Gastrointest Liver Physiol. 2002 Nov;283(5):G1147-55. doi:

10.1152/ajpgi.00184.2002. PMID: 12381529.

43: Chu J, Chu S, Montrose MH. Apical Na+/H+ exchange near the base of mouse

colonic crypts. Am J Physiol Cell Physiol. 2002 Jul;283(1):C358-72. doi:

10.1152/ajpcell.01380.2000. PMID: 12055105.

44: Baumgartner HK, Kirbiyik U, Coskun T, Chu S, Montrose MH. Endogenous cyclo-

oxygenase activity regulates mouse gastric surface pH. J Physiol. 2002 Nov

1;544(3):871-82. doi: 10.1113/jphysiol.2002.024620. PMID: 12411530; PMCID:

PMC2290623.

45: Coskun T, Baumgartner HK, Chu S, Montrose MH. Coordinated regulation of

gastric chloride secretion with both acid and alkali secretion. Am J Physiol

Gastrointest Liver Physiol. 2002 Nov;283(5):G1147-55. doi:

10.1152/ajpgi.00184.2002. PMID: 12381529.

46: Chu J, Chu S, Montrose MH. Apical Na+/H+ exchange near the base of mouse

colonic crypts. Am J Physiol Cell Physiol. 2002 Jul;283(1):C358-72. doi:

10.1152/ajpcell.01380.2000. PMID: 12055105.

47: Coskun T, Chu S, Montrose MH. Intragastric pH regulates conversion from net

acid to net alkaline secretion by the rat stomach. Am J Physiol Gastrointest

Liver Physiol. 2001 Oct;281(4):G870-7. doi: 10.1152/ajpgi.2001.281.4.G870. PMID:

11557506.

48: Lyall V, Alam RI, Phan DQ, Ereso GL, Phan TH, Malik SA, Montrose MH, Chu S,

Heck GL, Feldman GM, DeSimone JA. Decrease in rat taste receptor cell

intracellular pH is the proximate stimulus in sour taste transduction. Am J

Physiol Cell Physiol. 2001 Sep;281(3):C1005-13. doi:

10.1152/ajpcell.2001.281.3.C1005. PMID: 11502578.

49: Maouyo D, Chu S, Montrose MH. pH heterogeneity at intracellular and

extracellular plasma membrane sites in HT29-C1 cell monolayers. Am J Physiol

Cell Physiol. 2000 May;278(5):C973-81. doi: 10.1152/ajpcell.2000.278.5.C973.

PMID: 10794671.

50: Chu S, Montrose MH. The glow of the colonic pH microclimate kindled by short-

chain fatty acids, chloride and bicarbonate. J Physiol. 1999 Jun 1;517 ( Pt

2)(Pt 2):315. doi: 10.1111/j.1469-7793.1999.0315t.x. PMID: 10332082; PMCID:

PMC2269355.

51: Chu S, Tanaka S, Kaunitz JD, Montrose MH. Dynamic regulation of gastric

surface pH by luminal pH. J Clin Invest. 1999 Mar;103(5):605-12. doi:

10.1172/JCI5217. PMID: 10074477; PMCID: PMC408122.

52: Chu S, Montrose MH. Transepithelial SCFA fluxes link intracellular and

extracellular pH regulation of mouse colonocytes. Comp Biochem Physiol A

Physiol. 1997 Oct;118(2):403-5. doi: 10.1016/s0300-9629(96)00329-5. PMID:

9366080.

53: Montrose MH, Chu S. Transepithelial SCFA gradients regulate polarized Na/H

exchangers and pH microdomains in colonic epithelia. Comp Biochem Physiol A

Physiol. 1997 Oct;118(2):389-93. doi: 10.1016/s0300-9629(96)00326-x. PMID:

9366077.

54: Chu S, Montrose MH. Non-ionic diffusion and carrier-mediated transport drive

extracellullar pH regulation of mouse colonic crypts. J Physiol. 1996 Aug 1;494

( Pt 3)(Pt 3):783-93. doi: 10.1113/jphysiol.1996.sp021532. PMID: 8865074; PMCID:

PMC1160677.

55: Chu S, Brownell WE, Montrose MH. Quantitative confocal imaging along the

crypt-to-surface axis of colonic crypts. Am J Physiol. 1995 Dec;269(6 Pt

1):C1557-64. doi: 10.1152/ajpcell.1995.269.6.C1557. PMID: 8572186.

56: Chu S, Montrose MH. An Na(+)-independent short-chain fatty acid transporter

contributes to intracellular pH regulation in murine colonocytes. J Gen Physiol.

1995 May;105(5):589-615. doi: 10.1085/jgp.105.5.589. PMID: 7658194; PMCID:

PMC2216952.

57: Chu S, Montrose MH. Extracellular pH regulation in microdomains of colonic

crypts: effects of short-chain fatty acids. Proc Natl Acad Sci U S A. 1995 Apr

11;92(8):3303-7. doi: 10.1073/pnas.92.8.3303. PMID: 7724557; PMCID: PMC42154.

58: Chu S, Kennedy JR. Intra-epithelial palatine nerve endings and their

regulation of ciliary activity of frog palate epithelium. J Comp Physiol A. 1994

Oct;175(4):505-18. doi: 10.1007/BF00199257. PMID: 7965919.