Lawrence A. Quilliam, PhD
Professor of Biochemistry & Molecular Biology
- Phone
- (317) 274-8550
- Address
-
635 Barnhill Drive
Medical Science, Room MS4075G
Indianapolis, IN 46202 - PubMed:
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Bio
Dr. Quilliam received his PhD in Biochemistry from the University of Sheffield, England where he studied cell signaling events that regulate pituitary hormone secretion. His postdoctoral training focused on the discovery and characterization of Ras family small GTP binding proteins, their regulators, effectors, and the biological/pathological processes that they control. This work, performed in the laboratories of Drs. Joan Heller Brown (UCSD), Gary Bokoch (The Scripps Research Institute) and Channing Der (La Jolla Cancer Research Foundation and University of North Carolina, Chapel Hill), provided a strong foundation in biochemical and molecular techniques and a disciplined approach to solving biological questions. Dr. Quilliam’s laboratory at IU School of Medicine has continued this tradition since 1995. Using molecular, cellular and in vivo models, his students and postdoctoral fellows have contributed to the discovery and characterization of multiple cell signaling events associated with cell growth and cancer.Key Publications
For a complete list of publications, visit PubMed| Year | Degree | Institution |
|---|---|---|
| 1986 | PhD | University of Sheffield |
| 1983 | BSC | University of Manchester |
The Quilliam lab is interested in delineating signal transduction pathways induced by growth-stimulatory factors, and in determining the mechanisms by which these pathways are aberrantly activated during the course of malignant transformation. Many of the genes that become mutated in human cancers encode for mitogenic signaling proteins. Characterization of the enzymes and protein-protein interactions involved in mitogenic signaling forms the basis for the rational design of novel anti-cancer therapeutics. Much of the focus of Dr. Quilliam’s research is centered on Ras family GTPases and the pathways they control. Ras proteins normally act as molecular switches to relay growth stimulatory signals but become constitutively activated in many cancers, leading to uncontrolled proliferation. The Ras onco-proteins are frequently mutated in pancreatic cancer, a malignancy with a dismal survival rate. Therefore, current lab efforts are addressing ways to combat Ras-induced transformation in pancreatic ductal adenocarcinoma cells through the simultaneous inhibition of pathways activated by Ras along with those, e.g. Yap/Taz transcriptional co-activators, that compensate for loss of Ras activity. Independently, mouse models have been developed to understand the molecular and biological roles of Rap1, one of over 30 Ras-related proteins. Rap1A and 1B contribute to leukocyte (myeloid) and endothelial cell pathologies and also impact tumor growth and metastasis. RAP1 knockout mice are being used to study these events.
Small GTPase Rap1 Is Essential for Mouse Development and Formation of Functional Vasculature.
Chrzanowska-Wodnicka M; White GC 2nd; Quilliam LA; Whitehead KJ; PloS one 2015 Dec 29
Chrzanowska-Wodnicka M; White GC 2nd; Quilliam LA; Whitehead KJ; PloS one 2015 Dec 29
Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.
Babcock JT; Nguyen HB; He Y; Hendricks JW; Wek RC; Quilliam LA; The Journal of biological chemistry 2013 Apr 23
Babcock JT; Nguyen HB; He Y; Hendricks JW; Wek RC; Quilliam LA; The Journal of biological chemistry 2013 Apr 23
PI3-kinase ? promotes Rap1a-mediated activation of myeloid cell integrin a4ß1, leading to tumor inflammation and growth.
Schmid MC; Franco I; Kang SW; Hirsch E; Quilliam LA; Varner JA; PloS one 2013 Apr 2
Schmid MC; Franco I; Kang SW; Hirsch E; Quilliam LA; Varner JA; PloS one 2013 Apr 2
LKB1 tumor suppressor regulates AMP kinase/mTOR-independent cell growth and proliferation via the phosphorylation of Yap.
Nguyen HB; Babcock JT; Wells CD; Quilliam LA; Oncogene 2012 Oct 1
Nguyen HB; Babcock JT; Wells CD; Quilliam LA; Oncogene 2012 Oct 1
Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions.
Yan J; Li F; Ingram DA; Quilliam LA; Molecular and cellular biology 2008 Jul 14
Yan J; Li F; Ingram DA; Quilliam LA; Molecular and cellular biology 2008 Jul 14
Org: Indiana University
Desc: Trustee Teaching Award
Scope: University
Date: 2024-04-01
Desc: Trustee Teaching Award
Scope: University
Date: 2024-04-01
Org:
Desc: Trustee Teaching Award
Scope: University
Date: 2008-05-01
Desc: Trustee Teaching Award
Scope: University
Date: 2008-05-01
Org:
Desc: Trustee Teaching Award
Scope: University
Date: 2003-05-01
Desc: Trustee Teaching Award
Scope: University
Date: 2003-05-01
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