Joel S. Corvera, MD
Professor of Clinical Surgery
- jcorvera@iu.edu
- Phone
- 317-923-1787
- Address
-
1801 N Senate Blvd-Suite 3300
Indianapolis, IN 46202 - PubMed:
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Bio
Dr. Corvera graduated magna cum laude from Duke University (1991) with degrees in Economics and Mathematics. After a brief career in investment banking, he completed postbaccalaureate premedical studies at Columbia University (1993). He earned his MD from Vanderbilt University School of Medicine (1998), where he was elected to the Alpha Omega Alpha Honor Medical Society. His surgical training includes a general surgery residency, cardiothoracic surgery research fellowship, and clinical cardiothoracic surgery fellowship at Emory University School of Medicine (1998-2008), followed by subspecialty training in aortic and endovascular surgery at the University of Florida College of Medicine (2009).
Dr. Corvera joined Indiana University Health in 2009 as a cardiovascular surgeon and became faculty at Indiana University School of Medicine in 2015. He currently serves as Director of Thoracic Vascular and Aortic Surgery, Surgical Director of Structural Heart Therapies, Director of Cardiothoracic Surgery Simulation, and Co-Director of the IU Health Aortic Center.
Key Publications
New Onset DQA1*0501+ Juvenile Dermatomyositis (JDMS): MRI Directed Muscle Biopsies (MBx): Immunohistochemistry and Lack of T Cell Receptor (TCR) V[beta]8 Oligoclonality. L.M. Pachman, M.R.G. O’Gorman, T.P. Lawton, D.L. Litt, J.S. Corvera, M.R. Liotta, L. Maduzia, J. Caliendo, V. Corrochano, M.W. Lingen, R.L. Pope. Pediatric Research, 1997;41(4):310.
2. Adenosine In Myocardial Protection In On-Pump And Off-Pump Cardiac Surgery. J. Vinten-Johansen, Z-Q Zhao, J.S. Corvera, C.D. Morris, J.M. Budde, V.H. Thourani, R.A. Guyton. Annals of Thoracic Surgery, 2003;75:S691-9.
3. Perfusion-Assisted Direct Coronary Artery Bypass Provides Early Reperfusion of Ischemic Myocardium and Facilitates Complete Revascularization. W.A. Cooper, J.S. Corvera, J.D. Puskas, O.M. Lattouf, R.A. Guyton. Annals of Thoracic Surgery, 2003;75:1132-39.
4. Pretreatment With Phenoxybenzamine Attenuates the Radial Artery’s Vasoconstrictor Response to Alpha Adrenergic Stimuli. J.S. Corvera, C.D. Morris, J.M. Budde, J.D. Puskas, O.M. Lattouf, W.A. Cooper, R.A. Guyton, J. Vinten-Johansen. Journal of Thoracic and Cardiovascular Surgery, 2003;126(5):1549-54.
5. Inhibition of Myocardial Injury by Ischemic Post-conditioning During Reperfusion: Comparison with Ischemic Preconditioning. Z-Q Zhao, J.S. Corvera, N-P Wang, M.E. Halkos, F. Kerendi, R.A. Guyton, J. Vinten-Johansen. American Journal of Physiology: Heart and Circulatory Physiology, 2003;285:H579-88.
6. Evaluation of Myocardial Performance with Conventional Single Site Ventricular Pacing and Biventricular Pacing in a Canine Model of Atrioventricular Block. P.A. Frias, J.S. Corvera, L.S. Schmarkey, M. Strieper, R.M. Campbell, J. Vinten-Johansen. Journal of Cardiovascular Electrophysiology, 2003;14(9):996-1000.
7. Optimal Dose and Mode Of Delivery Of Na+/H+ Exchange-1 Inhibitor Are Critical For Reducing Post-Surgical Ischemia-Reperfusion Injury. J.S. Corvera, Z-Q Zhao, L.S. Schmarkey, S. Katzmark, J.M. Budde, C.D. Morris, T. Ehring, R.A.Guyton, J. Vinten-Johansen. Annals of Thoracic Surgery, 2003;76:1614-22.
8. Postconditioning Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Events in the Early Minutes of Reperfusion. H. Kin, Z-Q Zhao, H-Y Sun, N-P Wang, J.S. Corvera, M.E. Halkos, F. Kerendi, R.A. Guyton, J. Vinten-Johansen. Cardiovascular Research, 2004;62:74-85.
9. Myocardial Protection with Postconditioning is Not Enhanced by Ischemic Preconditioning. M.E. Halkos, F. Kerendi, J.S. Corvera, N-P Wang, H. Kin, C.S. Payne, H-Y Sun, R.A. Guyton, J. Vinten-Johansen, Z-Q Zhao. Annals of Thoracic Surgery, 2004;78:961-9.
10. Inhibition of Myosin Light Chain Kinase Provides Prolonged Attenuation of Radial Artery
Vasospasm. F. Kerendi, M.E. Halkos, J.S. Corvera, H. Kin, Z-Q Zhao, M. Mosunjac, R.A.
Guyton, J. Vinten-Johansen. European Journal of Cardio-thoracic Surgery, 2004;26:1149–1155.
11. Polarized arrest with warm or cold adenosine/lidocaine blood cardioplegia is equivalent to hypothermic potassium blood cardioplegia. J.S. Corvera, H. Kin, G.P. Dobson, F. Kerendi, M.E. Halkos, S. Katzmark, C.S. Payne, Z-Q Zhao, R.A. Guyton, J. Vinten-Johansen. Journal of Thoracic and Cardiovascular Surgery, 2005;129(3):599-606.
12. Upregulation of hypoxia inducible factor is associated with attenuation of neuronal injury in neonatal piglets undergoing deep hypothermic circulatory arrest. F. Kerendi, M.E. Halkos, H. Kin, J.S. Corvera, D.J. Brat, M.B. Wagner, J. Vinten-Johansen, Z-Q Zhao, J.M. Forbess, K.R. Kanter, M.E. Kelley, P.M. Kirshbom. Journal of Thoracic and Cardiovascular Surgery, 2005;130(4):1079.
13. Minimally Invasive Surgical Cardiac Resynchronization Therapy: An Intermediate-Term Follow Up Study. J.S. Corvera, V.H. Thourani, J.D. Puskas, R.A. Guyton, O.M. Lattouf. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, 2007;2(1):40-7.
14. “Spot” ECGs Underestimate Atrial Fibrillation Recurrence After Surgical Ablation. J.D. Puskas, J.S. Corvera, A. Neill, P. Kilgo, T. Vassiliades, R.A. Guyton. Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery, 2008;3(1):7-11.
15. Characteristics of second primary lung malignancy in patients with known breast cancer. F. Kerendi, A. Gal, J.S. Corvera, M.E. Halkos, J.I. Miller, Jr. Southern Medical Journal, 2009;102(3):269-74.
16. Early and Late Results of Descending Thoracic and Thoracoabdominal Aneurysm Open Repair Using Deep Hypothermic Circulatory Arrest. J.W. Fehrenbacher, H. Siderys, C. Terry, J. Kuhn, J.S. Corvera. Journal of Thoracic and Cardiovascular Surgery, 2010:140:S154-60.
17. Long-Term Results with Cryopreserved Arterial Allografts (CPAs) in the Treatment of Graft or Primary Arterial Infections. R.A. McCready, M.A .Bryant, J.W. Fehrenbacher, D.J .Beckman, A.C. Coffey, J.S. Corvera, D.A. Hormuth, T.C. Wozniak. Journal of Surgical Research, 2011;168(1):e149-53.
18. Total Arch and Descending Thoracic Aortic Replacement By Left Thoracotomy. J.S. Corvera and J.W. Fehrenbacher. Annals of Thoracic Surgery, 2012;93(5):1510-16.
19. Open Repair of Chronic Aortic Dissections Using Deep Hypothermia and Circulatory Arrest. J.S. Corvera and J.W. Fehrenbacher. Annals of Thoracic Surgery, 2012;94(1):78-83.
20. Best Surgical Option for Thoracoabdominal Aneurysm Repair – The Open Approach. J.W. Fehrenbacher and J.S. Corvera. Annals of Cardiothoracic Surgery, 2012;1(3):334-338.
21. The ARCH Projects: design and rationale (IAASSG 001). Yan TD, Tian DH, LeMaire SA, Misfeld M, Elefteriades JA, Chen EP, Hughes GC, Kazui T, Griepp RB, Kouchoukos NT, Bannon PG, Underwood MJ, Mohr FW, Oo A, Sundt TM, Bavaria JE, Di Bartolomeo R, Di Eusanio M, Roselli EE, Beyersdorf F, Carrel TP, Corvera JS, Della Corte A, Ehrlich M, Hoffman A, Jakob H, Matalanis G, Numata S, Patel HJ, Pochettino A, Safi HJ, Estrera A, Perreas KG, Sinatra R, Trimarchi S, Sun LZ, Tabata M, Wang C, Haverich A, Shrestha M, Okita Y, Coselli J. European Journal of Cardiothoracic Surgery, 2014;45(1):10-6. .
22. Transcatheter Aortic Valve Replacement Versus Aortic Valve Bypass: A Comparison of
Outcomes and Economics. Brown JB, Boyd JH, Patel PM, Baker ML, Syed A, Ladowski J,
Corvera J. Annals of Thoracic Surgery, 2016;101:49-55.
23. Open Repair of Chronic Thoracic and Thoracoabdominal Aortic Dissection Using Deep
Hypothermia and Circulatory Arrest. J.S. Corvera, H. Copeland, D. Blitzer, A. Hicks, J.
Manghelli, P.J. Hess, J.W. Fehrenbacher. Journal of Thoracic and Cardiovascular Surgery, 2017;154:389-95.
24. Repair of Thoracic and Thoracoabdominal Mycotic Aneurysms And Infected Aortic Grafts Using Allograft. J.S. Corvera, D. Blitzer, H. Copeland, D. Murphy, P.J. Hess, Jr., S.T. Pillai, J.W. Fehrenbacher. Annals of Thoracic Surgery, 2018;106(4):1129-35.
25. The Addition of Aortic Root Procedures during Elective Arch Surgery Does Not Confer Added Morbidity nor Mortality. Keeling B, Tian D, Heinz J, Shresthra M, Fujikawa T, Corvera JS, DiEusanio M, Leshnower B, Chen EP. Annals of Thoracic Surgery, 2019;108:452-7.
26. A 20-year Multicenter Analysis of Dialysis-Dependent Patients Who Had Aortic or Mitral Valve Replacement: Implications for Valve Selection. Manghelli JL, Carter DI, Khiabani AJ, Gauthier JM, Moon MR, Munfakh NA, Damiano RJ, Corvera JS, Melby SJ. Journal of Thoracic and Cardiovascular Surgery, 2019;158:805-13.
27. Blunt aortic injuries in the new era: radiologic findings and polytrauma risk assessment dictates management strategy. Payne NE, Nygaard RM, Fernandez JD, Sahgal P, Richardson CJ, Bashir M, Parekh K, Vardas PN, Suzuki Y, Corvera J, Krook JC, Calcaterra D. European Journal of Trauma and Emergency Surgery, 2019;45:951-7.
28. The Presence of a Dedicated Cardiac Surgical Intensive Care Service Impacts Clinical Outcomes in Adult Cardiac Surgery Patients. LS Lee, AJ Clark, N Namburi, C Naum, LR Timsina, JS Corvera, DJ Beckman, JE Everett, PJ Hess. Journal of Cardiac Surgery, 2020;35:787-73.
29. Eleven-Year Experience Treating Blunt Thoracic Aortic Injury at a Tertiary Referral Center. CM McCurdy, Z Faiza, N Namburi, TJ Hartman, JS Corvera, P Jenkins, LR Timsina, LS Lee. Annals of Thoracic Surgery, 2020;110:524-30.
30. Impact of troponin I level on coronary artery bypass grafting outcomes. Morone EJ, Barker SJ, Martinez Licha CR, Timsina LR, Namburi N, Milward JB, Everett JE, Corvera JS, Beckman DJ, Hess PJ Jr, Lee LS. Journal of Cardiac Surgery, 2020;35(10):2704-09.
31. Aortic root valve-sparing repair and dissections in Marfan syndrome during pregnancy: A case series. J Cottrell, J Calhoun, J Szczepanski, J Corvera, LL Creswell, B Kogon, N Hasaniya, H Copeland. Journal of Cardiac Surgery, 2020;35(7):1439-43.
32. Outcomes of surgical coronary revascularization performed pre-solid abdominal organ transplant. Matthews CR, Millward JB, Faiza Z, Namburi N, Timsina L, Hess PJ, Corvera JS, Everett JE, Beckman DJ, Lee LS. Annals of Thoracic Surgery, 2021;111:568-75.
33. An emergent nexus between striae and the severity of thoracic aortopathy. Landis B, Vujakovich, C, Elmore, L, Pillai S, Lee L, Everett J, Markham L, Brown J, Hess, P, Corvera J. Genes, 2021;13(1):23.
34. Identification of a common polymorphism in COQ8B acting as a modifier of thoracic aortic aneurysm severity. Landis BJ, Lai D, Guo D-C, Corvera JS, Idress MT, Stadler HW, Cuevas C, Needler GU, Vujakovich CE, Milewicz DM, Hinton RB, Ware SM. Human Genetics and Genomics Advances, 2022;3(1):100057.
35. One-Year Results with a Low-Profile Endograft in Subjects with Thoracic Aortic Aneurysm and Ulcer Pathologies. Szeto WY, Vallabhajosyula P, Matsuda S, Moainie S, Sharafuddin M, Corvera JS, Smolock C, Miyamoto S, Naslund, T, Ramaiah V. Journal of Thoracic and Cardiovascular Surgery, 2022;163(5):1739-1750.
36. Effects of RBT-1 on preconditioning response biomarkers in patients undergoing coronary artery bypass graft or heart valve surgery: a multicentre, double-blind, randomised, placebo-controlled phase 2 trial. ALamy, G Chertow, M Jessen, A Collar, C Brown, C Mack, M Marzouk, V Scavo, TB Washburn, D Savage, J Smith, J Bennetts, R Assi, C Shults, A Arghami, D Tedesco, J MacArthur, J Praetor, D Gandhi, J Corvera, J Butler, PJ Devereaux, A Browne, C Wang, S Snapinn, R Zager, J Rodriguez, S Ruiz, B Singh. eClinicalMedicine, 2024;68:102364.
37. Early survival benefit of a low-profile endograft in blunt traumatic aortic injury. BW Starnes, RR Rajani, P Rossi, N Singh, J Benarroch-Gampel, JS Cho, N Nassiri, MR Smeds, V Kalapatapu, JR Stern, N-K Kabutey, J Corvera. Journal of Vascular Surgery, 2024:80(3):678-684.e1.
38. A Comparative Analysis of Negative Pressure Wound Therapy Methods for Sternal Wound Infections. Bamba R, Harvey B, Malik NU, Higgins J, Sung C, Corvera JS, Hartman BC, Hassanein AH, Lester ME. Plastic & Reconstructive Surgery-Global Open, 2025;13(3):e6579.
39. Combines genome and transcriptome analysis identifies molecular signatures of aortic disease in patients with Marfan Syndrome. Stanley KB, Mederos AV, Barksdale EH, Corvera JS, Davis JL, Fang F, Gao H, Vujakovich CE, Liu Y, Ware SM, Landis BJ. Journal of Molecular and Cellular Cardiology Plus, 2025;13: 100467.
40. Long Term Outcomes of TEVAR For Blunt Thoracic Aortic Injury. M Kumar, M Madison, R Brenner, H Aridi, J Corvera, A Fajardo, RL Motaganahalli. Vascular and Endovascular Surgery, 2026, in press.
| Year | Degree | Institution |
|---|---|---|
| 2009 | Fellowship | University of Florida College of Medicine |
| 2008 | Residency | Emory University School of Medicine |
| 2005 | Residency | Emory University School of Medicine |
| 1998 | MD | Vanderbilt University |
| 1991 | AB | Duke University |
Dr. Corvera's research focuses on the pathogenesis of aortopathy, genetic modifiers of aortic disease severity, and outcomes of novel surgical and endovascular techniques for aortic repair. He has served as principal or co-investigator on multiple industry-sponsored and investigator-initiated clinical trials evaluating innovative devices and therapeutic approaches for aortic disease, including trials with Gore, Edwards LifeSciences, Cook Medical, Bolton Medical, CryoLife, and others.
Clinical Trial Profile
1. W. L. Gore & Associates, The Endovascular Treatment of Acute, Complicated Type B Aortic Dissection using the Gore conformable TAG thoracic endograft, Investigator.
2. Edwards LifeSciences, The PARTNER II Trial and Registries, Edwards Sapien XT and Sapien 3 Transcatheter Aortic Valve Trials, Investigator.
3. Cook Medical Inc., The Treatment of Thoracic Aneurysms and Penetrating Aortic Ulcers with the Low-Profile Zenith Alpha Thoracic Endograft, Investigator.
4. Bolton Medical (Terumo Aortic) Bolton Relay Pro thoracic endograft for the treatment of thoracic aneurysm and aortic transection, Investigator.
5. Cytosorbents Corporation, CytoSorb® Reduction of Free Hemoglobin/Acute Kidney
Injury (AKI) During Cardiac Surgery (REFRESH II-AKI), Investigator.
7. CryoLife, Inc., PROACT Xa, A prospective, randomized, active (warfarin) controlled parallel-arm clinical trial to determine if patients with an On-X aortic valve can be maintained safely and effectively on the factor Xa inhibitor apixaban, Investigator.
8. W. L. Gore & Associates, Evaluation of the Gore Excluder Thoracoabdominal Branch
Endoprosthesis (TAMBE) in the treatment of thoracoabdominal and pararenal aneurysms (AAA-17-01), Investigator.
9. Cardiothoracic Surgical Trials Network, Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG (PACES), Investigator.
11. Renibus Therapeutics, Inc., REN-004, a Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of RBT-1 on Preconditioning Response Biomarkers in Subjects Undergoing Coronary Artery Bypass Graft (CABG) and/or Valve Surgery (The START Trial), Investigator.
12. Renibus Therapeutics, Inc., REN-007, a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of RBT-1 on Reducing the Risk of Post-Operative Complications in Subjects Undergoing Cardiac Surgery, Investigator.
13. W.L. Gore & Associates, Inc., ARISE II: Evaluation of the Gore Ascending Stent Graft in the Treatment of Lesions of the Ascending Aorta (ASG 22-02), Investigator.
14. W. L. Gore & Associates, Evaluation of the Gore Excluder Thoracoabdominal Branch
Endoprosthesis (TAMBE) in the treatment of thoracoabdominal and pararenal aneurysms, post -approval registry (AAA 24-01), Investigator.
15. IMPRoving Outcomes in Vascular DisEase- Aortic Dissection (IMPROVE-AD, NCT 06087029), Investigator.
16. Zenith® Fenestrated+ Endovascular Graft Clinical Study, Investigator.
17. W. L. Gore & Associates, TOGETHER Registry, Long-Term Characterization of the Gore TAG Conformable Thoracic Stent Graft with Active Control System Performance (TGR23-02TA), Investigator.
18. W.L. Gore & Associates, Inc., ARISE III: Evaluation of the Gore Ascending Stent Graft in the Treatment of Acute Dissection of the Ascending Aorta (ASG 24-02), Investigator.
Dr. Corvera specializes in complex aortic surgery with extensive experience in open and endovascular repair of thoracic and thoracoabdominal aortic aneurysms and dissections. His expertise includes transcatheter valve therapies, surgical management of aortic root and arch aneurysms, endovascular aortic interventions, and treatment of aortic infections. As Co-Director of the IU Health Aortic Center, he leads a comprehensive regional referral center for complex aortic pathology.