Dipika Gupta, PhD

Bio

Dr. Gupta is an Associate Professor of Biochemistry and Molecular Biology at Indiana University School of Medicine. Her research has discovered a new family of innate immunity proteins and identified their role in the regulation of microbiome, host-bacterial interactions, and development of inflammatory disease, including obesity and colitis. These discoveries enhance our understanding of the host-microbe interactions and their role in pathogenesis and will also pave the way for the development of new approaches for the prevention and treatment of inflammatory diseases. Dr. Gupta is the course director and a lecturer for the course Molecules to Cells and Tissues taught to first-year medical students.

Selected peer-reviewed research publications

1.      Li, X, Wang, S, Qi, J, Echtenkamp, SF, Chatterjee, R, Wang, M, Boons, G-B, Dziarski, R, and Gupta, D. 2007. Zebrafish peptidoglycan recognition proteins are bactericidal amidases essential for defense against bacterial infections. Immunity, 27:518-527, PMID: 17892854
2.      Gupta, D. 2008. Peptidoglycan recognition proteins-maintaining immune homeostasis and normal development. Cell Host & Microbe, 15:273-274, (invited preview) PMID: 18474351
3.      Saha, S, Qi, J, Wang, S, Wang, M, Li, X, Kim, Y-G, Nunez, G, Gupta, D, and Dziarski, R. 2009. PGLYRP-2 and Nod2 are both required for peptidoglycan-induced arthritis and local inflammation. Cell Host and Microbe, 5:137-150, PMID: 19218085
4.      Saha, S, Jing, X, Park, SH, Wang, S, Li, X, Gupta, D, and Dziarski, R. 2010. Peptidoglycan recognition proteins protect mice from inflammatory bowel disease by promoting normal gut flora and preventing induction of interferon-gamma. Cell Host and Microbe, 8:147-162. PMID: 20709292
5.      Kashyap, DR, Wang, M, Liu, L-H, Boons, G-J, Gupta, D, Dziarski, R. 2011. Peptidoglycan Recognition Proteins kill bacteria by activating protein-sensing two-component systems. Nature Medicine, 17:676-683 (featured in a Commentary in the same issue of the journal). PMID: 21602801
6.      Park, SY, Gupta, D, Kim, CH, and Dziarski, R. 2011. Differential effects of peptidoglycan recognition proteins on experimental atopic and contact dermatitis mediated by Treg and Th17 cells. PLoS One, 6: e24961. p. 1-16, doi: 10.1371/journal.pone.0024961. PMID: 21949809
7.      Park, SY, Gupta, D, Hurwich, R, Kim, CH, and Dziarski, R. 2011. Peptidoglycan recognition protein Pglyrp2 protects mice from psoriasis-like skin inflammation by promoting regulatory T cells and limiting Th17 responses. Journal of Immunology, 187: 5813-5823. PMID: 22048773
8.      Park SY, Jing X, Gupta D, Dziarski R. 2013. Peptidoglycan recognition protein 1 enhances experimental asthma by promoting Th2 and Th17 and limiting regulatory T cell and plasmacytoid dendritic cell responses. Journal of Immunology, 190:3480-3492, PMID: 23420883
9.      Zulfiqar F, Hozo I, Rangarajan S, Mariuzza R, Dziarski R, Gupta D. 2013. Genetic association of peptidoglycan recognition protein variants with inflammatory bowel disease. PLoS One, 8: e67393, p.1-14, doi:10.1371/journal.pone.0067393. PMID: 23840689
10.    Kashyap DR, Rompca A, Gaballa A, Helmann JD, Chan J, Chang CJ, Hozo I, Gupta D, Dziarski. R. 2014. Peptidoglycan recognition proteins kill bacteria by inducing oxidative, thiol, and metal stress. Plos Pathogens, 10: e1004280, doi: 10.1371/journal.ppat.1004280. PMID: 25032698
11.    Jing X, Zulfiqar F, Park SY, Nunez G, Dziarski R, Gupta D. 2014. Peptidoglycan recognition protein 3 and Nod2 synergistically protect mice from dextran sodium sulfate-induced colitis. Journal of Immunology , 193: 3055-3069. PMID: 25114103
12.    Dziarski, R, Park SY, Kashyap DR, Dowd, S, Gupta D. 2016. Pglyrp-regulated gut microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii enhance and Alistipes finegoldii attenuates colitis in mice. PLoS One, 11(1):e0146162. doi:10.1371/ journal.pone.0146162. PMID: 26727498