26759-Enane, Leslie

Leslie A. Enane, MD, 998

Associate Professor of Pediatrics

Phone
(317) 944-7260
Address
705 Riley Hospital Drive

Indianapolis, IN 46202
PubMed:

Bio

Leslie A. Enane, MD, MSc, is an Associate Professor of Pediatrics in the Ryan White Center for Pediatric Infectious Disease and Global Health at Indiana University School of Medicine, and she serves as the Director of Pediatric HIV Services at Riley Hospital for Children. Her global health research centers on TB and HIV care for children, adolescents, and young adults. She uses epidemiologic and implementation science methods to investigate clinical outcomes, assess drivers of care engagement, and develop interventions in partnership with youth. She is an investigator collaborating in the Academic Model Providing Access to Healthcare (AMPATH) Consortium, and in the East Africa region of the NIH-funded International Epidemiologic Database to Evaluate AIDS (IeDEA). She serves as Co-Chair of the Multiregional TB Sentinel Research Network of IeDEA. She has collaborated on evidence reviews and consensus statements that have informed global TB policies. This has included collaboration in an evidence review to inform the 2022 World Health Organization (WHO) consolidated guidelines and operational handbook on managing tuberculosis in children and adolescents, and more recently in the WHO consensus statement on optimal and early inclusion of pregnant and lactating women in tuberculosis research.

Key Publications

Enane LA, Duda SN, Chanyachukul T, Bolton-Moore C, Navuluri N, Messou E, Mbonze N, McDade LR, Figueiredo MC, Ross J, Evans D, Diero L, Akpata R, Zotova N, Freeman A, Pierre MF, Rupasinghe D, Ballif M, Byakwaga H, de Castro N, Tabala M, Sterling TR, Sohn AH, Fenner L, Wools-Kaloustian K, Poda A, Yotebieng M, Huebner R, Marcy O; International epidemiology Databases to Evaluate AIDS. The Tuberculosis Sentinel Research Network (TB-SRN) of the International epidemiology Databases to Evaluate AIDS (IeDEA): protocol for a prospective cohort study in Africa, Southeast Asia and Latin America. BMJ Open. 2024 Jan 9;14(1):e079138. doi: 10.1136/bmjopen-2023-079138. PMID: 38195167; PMCID: PMC10806577.

Chiang SS, Waterous PM, Atieno VF, Bernays S, Bondarenko Y, Cruz AT, de Oliveira MCB, Del Castillo Barrientos H, Enimil A, Ferlazzo G, Ferrand RA, Furin J, Hoddinott G, Isaakidis P, Kranzer K, Maleche-Obimbo E, Mansoor H, Marais BJ, Mohr-Holland E, Morales M, Nguyen AP, Oliyo JO, Sant'Anna CC, Sawyer SM, Schaaf HS, Seddon JA, Sharma S, Skrahina A, Starke JR, Triasih R, Tsogt B, Welch H, Enane LA. Caring for Adolescents and Young Adults With Tuberculosis or at Risk of Tuberculosis: Consensus Statement From an International Expert Panel. J Adolesc Health. 2023 Mar;72(3):323-331. doi: 10.1016/j.jadohealth.2022.10.036. PMID: 36803849; PMCID: PMC10265598.

Laycock K, Technau KG, Lelo P, Jantarabenjakul W, Yonaba C, Pinto J, Menser M, Maruri F, Odhiambo F, Rambiki E, Babakazo P, Nguyen VL, Folquet M, Machado DM, Kalema N, Muula G, Brazier E, Nguyen DQ, Dame J, Luque MT, Semeere A, Eley B, Yotebieng M, Kariminia A, Rouzier V, Byakwaga H, Marcy O, Enane LA. Tuberculosis Diagnosis, Treatment, and Prevention Services for Children Living with HIV in Low- and Middle-Income Countries: A Multiregional Site Survey. J Pediatric Infect Dis Soc. 2025 Jun 16;14(6):piaf050. doi: 10.1093/jpids/piaf050. PMID: 40425522; PMCID: PMC12257623.

Prabhudas-Strycker K, Waugh M, Bates B, Weaver B, Xu H, Khaitan A, Enane LA. Postpandemic Trends and Missed Opportunities in Prevention and Diagnosis of Pediatric HIV. Pediatr Infect Dis J. 2025 Apr 15;44(9):e312-e318. doi: 10.1097/INF.0000000000004822. PMID: 40233327; PMCID: PMC12333522.

Embleton L, Sudjaritruk T, Machado DM, Chihota B, Musabyimana F, Jesson J, Apondi E, Puthanakit T, Luque MT, van Dongen NE, Murenzi G, Amorissani-Folquet M, Kwena Z, Perreras N, Rouzier V, Lyamuya R, Anderson K, Elul B, Leroy V, Enane LA, Martin R, Lancaster K, Parcesepe AM, Vreeman R; IeDEA. Characterizing adolescent and youth-friendly HIV services: a cross-sectional assessment across 16 global sites. J Int AIDS Soc. 2025 Apr;28(4):e26437. doi: 10.1002/jia2.26437. PMID: 40181514; PMCID: PMC11968415.

Nafiseh AA, Weaver BA, Enane LA. Persistent Fever, Hypoxemia, and Respiratory Distress in a 3-Month-Old Infant. Pediatr Rev. 2025 Oct 1;46(10):581-585. doi: 10.1542/pir.2023-006168. PMID: 41027606.

Jaguga F, Aalsma MC, Enane LA, Turissini M, Kwobah EK, Apondi E, Barasa J, Kosgei G, Olando Y, Ott MA. A qualitative pilot study exploring the acceptability of a peer provider delivered substance use brief intervention from the perspective of youth in Kenya. Subst Abuse Treat Prev Policy. 2025 Feb 11;20(1):6. doi: 10.1186/s13011-025-00639-9. PMID: 39934864; PMCID: PMC11817832.

Liepmann CD, Nafiseh AA, Carlucci JG, Enane LA. Clinical Findings and Evaluation of Newborns Who Were Anonymously Surrendered. JAMA Netw Open. 2024 Jan 2;7(1):e2349853. doi: 10.1001/jamanetworkopen.2023.49853. PMID: 38165677; PMCID: PMC10762573.

Bosma CB, Toromo JJ, Ayers MJ, Foster ED, McHenry MS, Enane LA. Effects of economic interventions on pediatric and adolescent HIV care outcomes: a systematic review. AIDS Care. 2024 Jan;36(1):1-16. doi: 10.1080/09540121.2023.2240071. Epub 2023 Aug 22. PMID: 37607246; PMCID: PMC10843852.

Parcesepe AM, Stockton M, Remch M, Wester CW, Bernard C, Ross J, Haas AD, Ajeh R, Althoff KN, Enane L, Pape W, Minga A, Kwobah E, Tlali M, Tanuma J, Nsonde D, Freeman A, Duda SN, Nash D, Lancaster K; IeDEA Consortium. Availability of screening and treatment for common mental disorders in HIV clinic settings: data from the global International epidemiology Databases to Evaluate AIDS (IeDEA) Consortium, 2016-2017 and 2020. J Int AIDS Soc. 2023 Aug;26(8):e26147. doi: 10.1002/jia2.26147. PMID: 37535703; PMCID: PMC10399924.

MacDonald KR, Enane LA, McHenry MS, Davis NL, Whipple EC, Ott MA. Ethical Aspects of Involving Adolescents in HIV Research: A Systematic Review of the Empiric Literature. J Pediatr. 2023 Nov;262:113589. doi: 10.1016/j.jpeds.2023.113589. Epub 2023 Jul 1. PMID: 37399918; PMCID: PMC11119419.

Zürcher K, Cox SR, Ballif M, Enane LA, Marcy O, Yotebieng M, Reubenson G, Imsanguan W, Otero L, Suryavanshi N, Duda SN, Egger M, Tornheim JA, Fenner L; International Epidemiology Databases to Evaluate AIDS (IeDEA). Integrating services for HIV and multidrug-resistant tuberculosis: A global cross-sectional survey among ART clinics in low- and middle-income countries. PLOS Glob Public Health. 2022;2(3):e0000180. doi: 10.1371/journal.pgph.0000180. Epub 2022 Mar 1. PMID: 36778080; PMCID: PMC9910322.

Marti M, Zürcher K, Enane LA, Diero L, Marcy O, Tiendrebeogo T, Yotebieng M, Twizere C, Khusuwan S, Yunihastuti E, Reubenson G, Shah NS, Egger M, Ballif M, Fenner L; IeDEA global consortium. Impact of the COVID-19 pandemic on TB services at ART programmes in low- and middle-income countries: a multi-cohort survey. J Int AIDS Soc. 2022 Oct;25(10):e26018. doi: 10.1002/jia2.26018. PMID: 36285602; PMCID: PMC9597377.

Humphrey JM, Alera M, Enane LA, Kipchumba B, Goodrich S, Scanlon M, Songok J, Musick B, Diero L, Yiannoutsos C, Wools-Kaloustian K. Effects of the COVID-19 pandemic on late postpartum women living with HIV in Kenya. PLOS Glob Public Health. 2023 Mar 29;3(3):e0001513. doi: 10.1371/journal.pgph.0001513. PMID: 36989321; PMCID: PMC10058168.

Bernard C, Hassan SA, Humphrey J, Thorne J, Maina M, Jakait B, Brown E, Yongo N, Kerich C, Changwony S, Qian SRW, Scallon AJ, Komanapalli SA, Enane LA, Oyaro P, Abuogi LL, Wools-Kaloustian K, Patel RC. Impacts of the COVID-19 pandemic on access to HIV and reproductive health care among women living with HIV (WLHIV) in Western Kenya: A mixed methods analysis. Front Glob Womens Health. 2022 Dec 12;3:943641. doi: 10.3389/fgwh.2022.943641. PMID: 36578364; PMCID: PMC9790904.

Brazier E, Maruri F, Wester CW, Musick B, Freeman A, Parcesepe A, Hossmann S, Christ B, Kimmel A, Humphrey J, Freeman E, Enane LA, Lancaster KE, Ballif M, Golub JE, Nash D, Duda SN; International epidemiology Databases to Evaluate AIDS (IeDEA) consortium. Design and implementation of a global site assessment survey among HIV clinics participating in the International epidemiology Databases to Evaluate AIDS (IeDEA) research consortium. PLoS One. 2023 Mar 14;18(3):e0268167. doi: 10.1371/journal.pone.0268167. PMID: 36917598; PMCID: PMC10013879.

Enane LA, Apondi E, Liepmann C, Toromo JJ, Omollo M, Bakari S, Scanlon M, Wools-Kaloustian K, Vreeman RC. 'We are not going anywhere': a qualitative study of Kenyan healthcare worker perspectives on adolescent HIV care engagement during the COVID-19 pandemic. BMJ Open. 2022 Mar 30;12(3):e055948. doi: 10.1136/bmjopen-2021-055948. PMID: 35354627; PMCID: PMC8968109.

Posada R, Waldman R, Chory A, Martin R, Cohen A, Chiacchia S, Childs J, Enane LA, Vreeman R. Longitudinal impacts of the COVID-19 pandemic on adolescents living with HIV in New York City. AIDS Care. 2023 May;35(5):629-633. doi: 10.1080/09540121.2022.2090491. Epub 2022 Jun 27. PMID: 35761785; PMCID: PMC11119397.

Toromo JJ, Apondi E, Nyandiko WM, Omollo M, Bakari S, Aluoch J, Kantor R, Fortenberry JD, Wools-Kaloustian K, Elul B, Vreeman RC, Enane LA. "I have never talked to anyone to free my mind" - challenges surrounding status disclosure to adolescents contribute to their disengagement from HIV care: a qualitative study in western Kenya. BMC Public Health. 2022 Jun 4;22(1):1122. doi: 10.1186/s12889-022-13519-9. PMID: 35658924; PMCID: PMC9167528.

Myers C, Apondi E, Toromo JJ, Omollo M, Bakari S, Aluoch J, Sang F, Njoroge T, Morris Z, Kantor R, Braitstein P, Nyandiko WM, Wools-Kaloustian K, Elul B, Vreeman RC, Enane LA. "Who am I going to stay with? Who will accept me?": family-level domains influencing HIV care engagement among disengaged adolescents in Kenya. J Int AIDS Soc. 2022 Feb;25(2):e25890. doi: 10.1002/jia2.25890. PMID: 35192747; PMCID: PMC8863355.

Moscibrodzki P, Enane LA, Hoddinott G, Brooks MB, Byron V, Furin J, Seddon JA, Meyersohn L, Chiang SS. The Impact of Tuberculosis on the Well-Being of Adolescents and Young Adults. Pathogens. 2021 Dec 8;10(12):1591. doi: 10.3390/pathogens10121591. PMID: 34959546; PMCID: PMC8706072.

Enane LA, Apondi E, Aluoch J, Bakoyannis G, Lewis Kulzer J, Kwena Z, Kantor R, Chory A, Gardner A, Scanlon M, Goodrich S, Wools-Kaloustian K, Elul B, Vreeman RC. Social, economic, and health effects of the COVID-19 pandemic on adolescents retained in or recently disengaged from HIV care in Kenya. PLoS One. 2021 Sep 10;16(9):e0257210. doi: 10.1371/journal.pone.0257210. PMID: 34506555; PMCID: PMC8432853.

Callen G, Chory A, Sang F, Munyoro D, Aluoch J, Scanlon M, Enane L, McHenry M, Wools-Kaloustian K, Apondi E, Vreeman R. A Qualitative Examination of Perceived Stigma and its Sources Among Adolescents Living With HIV in Western Kenya. Glob Pediatr Health. 2022 Jan 6;9:2333794X211065335. doi: 10.1177/2333794X211065335. PMID: 35024383; PMCID: PMC8744199.

Laycock KM, Enane LA, Steenhoff AP. Tuberculosis in Adolescents and Young Adults: Emerging Data on TB Transmission and Prevention among Vulnerable Young People. Trop Med Infect Dis. 2021 Aug 5;6(3):148. doi: 10.3390/tropicalmed6030148. PMID: 34449722; PMCID: PMC8396328.

Laycock KM, Eby J, Arscott-Mills T, Argabright S, Caiphus C, Kgwaadira B, Lowenthal ED, Steenhoff AP, Enane LA. Towards quality adolescent-friendly services in TB care. Int J Tuberc Lung Dis. 2021 Jul 1;25(7):579-583. doi: 10.5588/ijtld.21.0059. PMID: 34183104; PMCID: PMC8259119.

Enane LA, Apondi E, Omollo M, Toromo JJ, Bakari S, Aluoch J, Morris C, Kantor R, Braitstein P, Fortenberry JD, Nyandiko WM, Wools-Kaloustian K, Elul B, Vreeman RC. "I just keep quiet about it and act as if everything is alright" - The cascade from trauma to disengagement among adolescents living with HIV in western Kenya. J Int AIDS Soc. 2021 Apr;24(4):e25695. doi: 10.1002/jia2.25695. PMID: 33838007; PMCID: PMC8035676.

Enane LA, Eby J, Arscott-Mills T, Argabright S, Caiphus C, Kgwaadira B, Steenhoff AP, Lowenthal ED. TB and TB-HIV care for adolescents and young adults. Int J Tuberc Lung Dis. 2020 Feb 1;24(2):240-249. doi: 10.5588/ijtld.19.0416. PMID: 32127110; PMCID: PMC7307717.

Congdon M, Hong H, Young RR, Cunningham CK, Enane LA, Arscott-Mills T, Banda FM, Chise M, Motlhatlhedi K, Feemster K, Patel SM, Boiditswe S, Leburu T, Shah SS, Steenhoff AP, Kelly MS. Effect of Haemophilus influenzae Type b and 13-Valent Pneumococcal Conjugate Vaccines on Childhood Pneumonia Hospitalizations and Deaths in Botswana. Clin Infect Dis. 2021 Jul 15;73(2):e410-e416. doi: 10.1093/cid/ciaa919. PMID: 32634831; PMCID: PMC8282259.

Enane LA, Christenson JC. Global emerging resistance in pediatric infections with TB, HIV, and gram-negative pathogens. Paediatr Int Child Health. 2021 Feb;41(1):65-75. doi: 10.1080/20469047.2020.1853350. Epub 2020 Dec 11. PMID: 33305992; PMCID: PMC8243638.

Raciti CG, Enane LA, MacDonald KR, Whipple EC, Ott MA, McHenry MS. Ethical considerations for research involving pregnant women living with HIV and their young children: a systematic review of the empiric literature and discussion. BMC Med Ethics. 2021 Apr 1;22(1):38. doi: 10.1186/s12910-021-00601-x. PMID: 33794891; PMCID: PMC8017748.

Bhumbra S, Malin S, Kirkpatrick L, Khaitan A, John CC, Rowan CM, Enane LA. Clinical Features of Critical Coronavirus Disease 2019 in Children. Pediatr Crit Care Med. 2020 Oct;21(10):e948-e953. doi: 10.1097/PCC.0000000000002511. PMID: 32639466; PMCID: PMC7340139.

Enane LA, Apondi E, Toromo J, Bosma C, Ngeresa A, Nyandiko W, Vreeman RC. "A problem shared is half solved" - a qualitative assessment of barriers and facilitators to adolescent retention in HIV care in western Kenya. AIDS Care. 2020 Jan;32(1):104-112. doi: 10.1080/09540121.2019.1668530. Epub 2019 Sep 26. PMID: 31554414; PMCID: PMC6883166.

Enane LA, Lowenthal ED, Arscott-Mills T, Eby J, Caiphus C, Kgwaadira B, Coffin SE, Steenhoff AP. Investigating Outcomes of Adolescents and Young Adults (10-24 Years of Age) Lost to Follow-up from Tuberculosis Treatment in Gaborone, Botswana. Pediatr Infect Dis J. 2019 Oct;38(10):e271-e274. doi: 10.1097/INF.0000000000002369. PMID: 31220045; PMCID: PMC6768719.

Enane LA, Sullivan KV, Spyridakis E, Feemster KA. Clinical Impact of Malaria Rapid Diagnostic Testing at a US Children's Hospital. J Pediatric Infect Dis Soc. 2020 Jul 13;9(3):298-304. doi: 10.1093/jpids/piz022. PMID: 30989220; PMCID: PMC7358041.

Enane LA, Davies MA, Leroy V, Edmonds A, Apondi E, Adedimeji A, Vreeman RC. Traversing the cascade: urgent research priorities for implementing the 'treat all' strategy for children and adolescents living with HIV in sub-Saharan Africa. J Virus Erad. 2018 Nov 15;4(Suppl 2):40-46. doi: 10.1016/S2055-6640(20)30344-7. PMID: 30515313; PMCID: PMC6248846.

Sundararajan M, Enane LA, Kidwell LA, Gentry R, Danao S, Bhumbra S, Lehmann C, Teachout M, Yeadon-Fagbohun J, Krombach P, Schroeder B, Martin H, Winkjer J, Waltz T, Strysko J, Cope JR. Notes from the Field: Cronobacter sakazakii Meningitis in a Full-Term Neonate Fed Exclusively with Breast Milk - Indiana, 2018. MMWR Morb Mortal Wkly Rep. 2018 Nov 9;67(44):1248-1249. doi: 10.15585/mmwr.mm6744a7. PMID: 30408018; PMCID: PMC6223960.

Enane LA, Mokete K, Joel D, Daimari R, Tshume O, Anabwani G, Mazhani L, Steenhoff AP, Lowenthal ED. "We did not know what was wrong"-Barriers along the care cascade among hospitalized adolescents with HIV in Gaborone, Botswana. PLoS One. 2018 Apr 9;13(4):e0195372. doi: 10.1371/journal.pone.0195372. PMID: 29630654; PMCID: PMC5890999.

Enane LA, Vreeman RC, Foster C. Retention and adherence: global challenges for the long-term care of adolescents and young adults living with HIV. Curr Opin HIV AIDS. 2018 May;13(3):212-219. doi: 10.1097/COH.0000000000000459. PMID: 29570471.

Enane LA, Lowenthal ED, Arscott-Mills T, Matlhare M, Smallcomb LS, Kgwaadira B, Coffin SE, Steenhoff AP. Loss to follow-up among adolescents with tuberculosis in Gaborone, Botswana. Int J Tuberc Lung Dis. 2016 Oct;20(10):1320-1325. doi: 10.5588/ijtld.16.0060. PMID: 27725042.

Enane LA, Gastañaduy PA, Goldfarb DM, Pernica JM, Mokomane M, Moorad B, Masole L, Tate JE, Parashar UD, Steenhoff AP. Impact of Rotavirus Vaccination on Hospitalizations and Deaths From Childhood Gastroenteritis in Botswana. Clin Infect Dis. 2016 May 1;62 Suppl 2(Suppl 2):S168-74. doi: 10.1093/cid/civ1210. PMID: 27059352; PMCID: PMC4825886.

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