271-Philips, Santosh

Santosh Philips, PhD

Assistant Research Professor of Medicine

Email
sphilips@iu.edu
Address
Walther Hall
980 W Walnut St. C246
Indianapolis, IN 46202
PubMed:

Bio

Dr. Santosh Philips works across precision medicine, pharmacogenomics, and clinical informatics, with an emphasis on understanding patient variability and improving therapeutic decision-making through data-driven approaches. His research integrates translational pharmacogenomics and biomedical informatics, with prior work identifying and experimentally validating drug–gene interactions, drug repurposing opportunities, as well as genetic variants that influence gene activity and cellular viability. Across these efforts, Dr. Philips has applied machine learning and quantitative methods to integrate clinical and molecular data and generate biologically and clinically meaningful insights. Dr. Philips has contributed to numerous collaborative research initiatives and has authored more than 40 peer-reviewed publications. His current research centers on the development of analytical pipelines for biomarker discovery and predictive modeling, aimed at identifying individuals at risk for severe adverse drug reactions, including toxicities associated with chemotherapeutic agents. With training in pharmacy, bioinformatics, and business, Dr. Philips emphasizes rigorous evaluation, generalizability, and translational relevance in his work. A central focus of his work is ensuring that computational and molecular discoveries translate into reliable evidence that can support more effective, safer, and personalized therapies.

Key Publications

Philips S, Lu P, Fausel C, et al.
Association of heightened host and tumor immunity with prolonged duration of response to checkpoint inhibition across solid tumors.
Scientific Reports, 2025.

Shen F, Jiang G, Philips S, et al.
Cytochrome P450 oxidoreductase (POR) associated with severe paclitaxel-induced peripheral neuropathy in patients of European ancestry from ECOG-ACRIN E5103.
Clinical Cancer Research, 2023.

Wu X, Shen F, Jiang G, Xue, G, Philips S, et al.
A non-coding GWAS variant impacts anthracycline-induced cardiotoxic phenotypes in human iPSC-derived cardiomyocytes.
Nature Communications, 2022.

Shugg T, Ly RC, Rowe EJ, Philips S, et al.
Clinical opportunities for germline pharmacogenetics and management of drug-drug interactions in patients with advanced solid cancers.
JCO Precision Oncology, 2022.

Philips S, Wu HY, Li L.
Using machine learning algorithms to identify genes essential for cell survival.
BMC Bioinformatics, 2017.

Philips S, Zhou J, Li Z, et al.
A translational bioinformatic approach in identifying and validating an interaction between vitamin A and CYP19A1.
BMC Genomics, 2015.

Philips S, Richter A, Oesterreich S, et al.
Functional characterization of a genetic polymorphism in the promoter of the ESR2 gene.
Hormones and Cancer, 2012.

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