Juan F. Codocedo, PhD
Assistant Research Professor of Anatomy, Cell Biology & Physiology
- Phone
- (317) 287-7850
- Address
-
NB 107D
ANAT
IN
Indianapolis, IN
Bio
Dr. Juan F. Codocedo is an Assistant Research Professor at the Stark Neurosciences Research Institute, part of the Indiana University School of Medicine. He has dedicated his career to uncovering the molecular and cellular mechanisms underlying neurodegenerative diseases. His research and teaching focus on areas such as neuroinflammation, immunometabolism, and synaptic plasticity.
Dr. Codocedo, originally from Chile, began his scientific career in 2007 as a research fellow at the Pontifical Catholic University of Chile. He earned his PhD in Biological Sciences, specializing in Cellular and Molecular Biology, under the mentorship of Dr. Nibaldo Inestrosa, a world-renowned expert in Alzheimer’s disease. His doctoral research focused on the role of microRNAs in synaptic plasticity through non-canonical Wnt signaling. This work revealed novel mechanisms that influence neuronal function and memory.
After completing a postdoctoral fellowship in electrophysiology and synaptic remodeling at the same institution, Dr. Codocedo joined Indiana University in 2017. During his time there, he conducted postdoctoral research under Dr. Gary Landreth. In this role, he led studies focused on the function of brain-resident immune cells, particularly microglia, in Alzheimer’s disease. His research identified hexokinase 2 (HK2) as a crucial metabolic regulator of microglial function.
Dr. Codocedo has established an independent research program focused on the metabolic regulation of neuroinflammation in the contexts of neurodegenerative diseases and traumatic brain injuries. His research has received support from several organizations, including the Indiana Department of Health, the BrightFocus Foundation, and the Indiana Clinical and Translational Sciences Institute (CTSI). Additionally, he contributes to the academic mission of the Indiana University School of Medicine as co-Director of the Neuroimmunology course for the PhD program in Biomedical Sciences. Dr. Codocedo is also actively involved in mentoring postdoctoral researchers and graduate students.
Key Publications
Codocedo, J.F., Mera-Reina, C., Bor-Chian Lin, P., Fallen, P.B., Puntambekar, S.S., Casali, B.T., Jury-Garfe, N., Martinez, P., Lasagna-Reeves, C.A., and Landreth, G.E. 2024. Therapeutic targeting of immunometabolism reveals a critical reliance on hexokinase 2 dosage for microglial activation and Alzheimer’s progression. Cell Rep 43, 114488. https://doi.org/10.1016/j.celrep.2024.114488.
Wyatt-Johnson, S.K., Kersey, H.N., Codocedo, J.F., Newell, K.L., Landreth, G.E., Lamb, B.T., Oblak, A.L., and Brutkiewicz, R.R. 2023. Control of the temporal development of Alzheimer’s disease pathology by the MR1/MAIT cell axis. J Neuroinflammation 20, 78. https://doi.org/10.1186/s12974-023-02761-6.
Codocedo, J.F., and Landreth, G.E. 2022. The intersection of metabolism and inflammation is governed by the intracellular topology of hexokinases and the metabolic fate of glucose. Immunometabolism (Cobham (Surrey, England)) 4, e00011. https://doi.org/10.1097/IN9.0000000000000011.
Martinez, P., Patel, H., You, Y., Jury, N., Perkins, A., Lee-Gosselin, A., Taylor, X., You, Y., Viana Di Prisco, G., Huang, X., Dutta, S., Wijeratne, A. B., Redding-Ochoa, J., Shahid, S. S., Codocedo, J. F., Min, S., Landreth, G. E., Mosley, A. L., Wu, Y.-C., Lasagna-Reeves, C. A. 2022. Bassoon contributes to tau-seed propagation and neurotoxicity. Nature Neuroscience. doi:10.1038/s41593-022-01191-6
Moutinho, M.,* Codocedo, J.F.,* Puntambekar, S.S.,* and Landreth G. E. 2019. Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation. Annu. Rev. Pharmacol. Toxicol. 59:X–X. doi:10.1146/annurev-pharmtox-010818-021807. *These authors contributed equally to this article
Jay, T.R., Von Saucken V.E., Muñoz, B., Codocedo J.F., Atwood B.K., Lamb B.T., Landreth, G.E. 2019. TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment. Glia. doi: 10.1002/glia.23664
Codocedo, J.F., Inestrosa, N.C., 2016. Environmental control of microRNAs in the nervous system: Implications in plasticity and behavior. Neurosci. Biobehav. Rev. 60, 121–38. doi:10.1016/j.neubiorev.2015.10.010
Codocedo, J.F., Ríos, J.A., Godoy, J.A., Inestrosa, N.C., 2016. Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer’s Disease? Mol. Neurobiol. 53, 2320–38. doi:10.1007/s12035-015-9201-7
Codocedo, J.F., Allard, C., Godoy, J.A., Varela-Nallar, L., Inestrosa, N.C., 2012. SIRT1 Regulates Dendritic Development in Hippocampal Neurons. PLoS One 7, e47073. doi:10.1371/journal.pone.0047073
Codocedo, J.F., Rodríguez, F.E., Huidobro-Toro, J.P., 2009. Neurosteroids differentially modulate P2X ATP-gated channels through non-genomic interactions. J. Neurochem. 110, 734–44. doi:10.1111/j.1471-4159.2009.06166.x
| Year | Degree | Institution |
|---|---|---|
| 2014 | PhD | Pontifical Catholic University of Chile |
| 2011 | MS | Pontifical Catholic University of Chile |
| 2006 | BS | University of Santiago |
Dr. Codocedo’s research focuses on the relationship between immunometabolism and neurodegeneration. His laboratory investigates how changes in microglial metabolism, particularly through the enzyme HK2, impact inflammation, synaptic integrity, and the progression of Alzheimer’s disease and related disorders. His current projects include:
-Microglial HK2 in Aβ and Tau Crosstalk: This project examines how the regulation of metabolism via HK2 affects amyloid and tau pathologies and their interactions in Alzheimer’s disease.
-Microglial Metabolism in Traumatic Brain Injury (TBI): This research explores how metabolic changes in microglia, induced by TBI, may accelerate Alzheimer 's-like pathology.
- Subcellular Localization of HK2: This project aims to understand how HK2’s distribution within microglia influences their function during disease progression.
Future directions for his research include identifying new metabolic checkpoints in microglia, studying microglia-neuron interactions, and developing small-molecule modulators of microglial metabolism.
Desc: Alzheimer's Disease Research Grant
Scope: International
Date: 2021-01-01
Desc: Eli Lilly-Stark Neurosciences post-doctoral research Fellowship in Neurodegeneration
Scope: State
Date: 2020-01-01