42064-Wu, Wenting

Wenting Wu, PhD

Associate Research Professor of Medical & Molecular Genetics

Email
wuwent@iu.edu
Phone
(317) 274-3103
Address
ICO - 16 Tech Innovation Bldg 1 #4107
MMGE
IN
Indianapolis, IN

Bio

Dr. Wu earned her PhD from Fudan University and completed postdoctoral training in human genetics, bioinformatics, and genetic epidemiology at the University of California, San Diego, and Indiana University. She applies an integrative approach combining computational, comparative, and functional genomics to study complex disease mechanisms and advance personalized therapeutic interventions or treatments. Her research focuses on answering diabetes-related questions, including projects based on single cell resolution investigation of human circulating/pancreatic tissues in type 1 diabetes cohorts, and studies into the dynamics of transcriptional regulation of alternative splicing, chromatin regulation and remodeling in islets tissues, and linking those findings to circulating biomarkers in new-onset patients. Dr. Wu has published over 88 original research articles in peer-reviewed journals, accumulating more than 4,676 citations (Google Scholar, H-index = 31). She has presented her work widely at national/international conferences and serves as reviewer for multiple journals including Diabetes, Science Advances, Scientific Data, and Scientific Reports, etc. Dr. Wu’s work is supported by the NIDDK dkNET New Investigator Pilot Program in Bioinformatics, applying computational methods to quantify transcriptional changes and characterize tissue heterogeneity across multi-omic datasets. She serves as Associate Director of the Data and Analytics Core at the Center for Diabetes and Metabolic Disease (CDMD) and is a member of CDMD Executive Committee.

Key Publications

Full list of publications can be accessed at Google Scholar https://scholar.google.com/citations?hl=en&user=1dF9-s0AAAAJ&view_op=list_works&sortby=pubdate

Selected publications

  1. Webb-Robertson B*, Wu W* Flores J, Bramer L, Syed F, Tersey SA, May SC, Sims EK, Evans-Molina C, Mirmira RG: Distinct RNA Splicing Events in Whole Blood Differentiate Individuals with New-Onset Type 1 Diabetes from Healthy Controls.  The Journal of Clinical Endocrinology & Metabolism 2024 Sep 10:dgae622 (co-first author).
  2. K.Davidson R, Wu W, Kanojia S, Osmulski M, Casey N, M.Spaeth J: The Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Endocrine Cell Expansion and Differentiation in vivo. Diabetologia 2024 Oct;67(10):2275-2288.
  3. Lee CC, Kono T, Syed F, Weaver SA, Sohn P, Wu W, Chang G, Liu J, Slak Rupnik M, Evans-Molina C: Sodium butyrate prevents cytokine-induced beta-cell dysfunction through restoration of stromal interaction molecule 1 expression and activation of store-operated calcium entry. The FASEB Journal 2024, 38(15):e23853.
  4. Davidson RK, Kanojia S, Wu W, Kono T, Xu J, Osmulski M, Bone RN, Casey N, Evans-Molina C, Sims EK: The Chd4 helicase regulates chromatin accessibility and gene expression critical for β-cell function in vivo. Diabetes 2023:db220939.
  5. Sohn P, R.McLaughlin M, Krishnan P, Wu W, Rupnik M, Takasu A, Senda T, Lee C, Kono T, Evans-Molina C: Stromal Interaction Molecule 1 Maintains β Cell Identity and Function in Female Mice through Preservation of G Protein-Coupled Estrogen Receptor 1 Signaling. Diabetes 2023, 72(10):1433-1445.
  6. Pineros AR, Kulkarni A, Gao H, Orr KS, Glenn L, Huang F, Liu Y, Gannon M, Syed F, Wu W et al: Proinflammatory signaling in islet beta cells propagates invasion of pathogenic immune cells in autoimmune diabetes. Cell Reports 2022, 39(13):111011.
  7. Wu W, Syed F, Simpson E, Lee C, Liu J, Chang G, Dong C, Seitz C, L. Eizirik D, G. Mirmira R, Liu Y, Evans-Molina C: The Impact of Pro-Inflammatory Cytokines on Alternative Splicing Patterns in Human Islets. Diabetes 2021;71:116-127.(Cover Image)
  8. Kusmartseva I*, Wu W*, Syed F*, Van Der Heide V*, Jorgensen M*, Joseph P, Tang X, Candelario-Jalil E, Yang C, Nick H, et al. Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19. Cell Metabolism 2020, 32 (6) :1041-1051.e6 (Co-first author).
  9. Anderson-Baucum E, Piñeros AR, Kulkarni A, Webb-Robertson BJ, Maier B, Anderson RM, Wu W, Tersey SA, Mastracci TL, Casimiro I, Scheuner D, Metz TO, Nakayasu ES, Evans-Molina C, Mirmira RG. Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype. Cell Metabolism. 2021 Sep 7;33(9):1883-1893.
  10. Piñeros AR, Gao H, Wu W, Liu Y, Tersey SA, Mirmira RG: Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention. Metabolites 2020;10:513
  11. Visconti A, Duffy D, Liu F, Zhu G, Wu W, Cheng Y, Hysi P, Zeng C, Sanna M, Iles M, et al. Genome-wide association study in 176,678 Europeans reveals new genetic loci for tanning response to sun exposure. Nature Communications 2018, 9(1):1684.
  12. Zhang T, Choi J, Kovacs MA, Shi J, Xu M, NISC Comparative Sequencing Program, …, Wu W, et al. Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes. Genome Research2018,11: 1621-1635.
  13. Marshall C, Howrigan D, Merico D, Thiruvahindrapuram B, Wu W† (5th out of 268 coauthors), Scherer S, Neale B, Sebat J, on behalf of the Schizophrenia and CNV analysis groups of the Psychiatric Genomics Consortium: Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics 2017, 49, 27–35. († One of the lead authors).
  14. Chahal HS*, Wu W*, Ransohoff KJ, Yang L, Hedlin H, Desai M, Lin Y, Dai H-J, Qureshi AA, Li W-Q et al: Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma.  Nature Communications2016, 7:12510. (Co-first author).
  15. Wu W, Wagner EK, Hao Y, Rao X, Dai H, Han J, Chen J, Storniolo AMV, Liu Y, He C: Tissue-specific Co-expression of Long Non-coding and Coding RNAs Associated with Breast Cancer. Scientific Reports2016, 6:32731.
  16. Michaelson JJ, Shi Y, Gujral M, Zheng H, Malhotra D, Jin X, Jian M, Liu G, Greer D, Bhandari A, Wu W, et al: Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation. Cell, 2012, 151(7): 1431-1442.
  17. Wang H*, Wu W*, Wang H, Wang S, Chen Y, Zhang X, Yang J, Zhao S, Ding H, Lu D: Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance. Neuro-Oncology2010, 12(7): 679-686. (Co-first author).
  18. Wu W, Zhang W, Qiao R, Chen D, Wang H, Wang Y, Zhang S, Gao G, Gu A, Shen J et al: Association of XPD Polymorphisms with Severe Toxicity in Non-Small Cell Lung Cancer Patients in a Chinese Population. Clinical Cancer Research, 2009, 15(11): 3889-3895.

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