Zhenhui Chen, PhD
Associate Professor of Medicine
Adjunct Associate Professor of Anatomy, Cell Biology & Physiology
- Address
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Krannert Cardiovascular Research Center
1801 N. Senate Blvd., Suite E312 (E371 Mailing Address)
Indianapolis, IN 46202-1228 - PubMed:
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Bio
Dr. Zhenhui Chen is an Associate Professor within the Department of Medicine. His research focuses on biochemical and biophysical characterizations of ion transports (pumps and ion channels) in cardiac myocytes. Dr. Chen’s research has been funded by the NIH and AHA.
Dr. Chen earned his undergraduate degree from Nankai University and his PhD degree from Indiana University. He completed his research fellowships at Johns Hopkins University.
Key Publications
Chen Z, Song Y-L, Chen PS, Li X, Guo J. Na+, K+-Pump/Phospholemman Are Concentrated at Intercalated Discs for Conduction. Circ. Res. 2022 Jul 22;131(3):283-285. doi: 10.1161/CIRCRESAHA.122.321167. Epub 2022 Jun 30. PubMed PMID: 35770663; PubMed Central PMCID: PMC9308724.
He W, Huang D, Guo S, Wang D, Guo J, Cala SE and Chen Z. Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool. J Mol Cell Cardiol. 2020;143:107-119. doi.org/10.1016/j.yjmcc.2020.04.025. PMID: 32353354.
Chen M, Xu D, Wu AZ, Kranias EK, Lin SF, Chen PS, Chen Z. Phospholamban Regulates Nuclear Ca2+ Stores and Inositol 1,4,5-Trisphosphate Mediated Nuclear Ca2+ Cycling in Cardiomyocytes. J. Mol. Cell. Cardiol., 2018, Oct;123:185-197. PMID:30261161.
Wu AZ, Xu D, Yang N, Lin SF, Chen PS, Cala SE, Chen Z. Phospholamban is concentrated in the nuclear envelope of cardiomyocytes and involved in perinuclear/nuclear calcium handling. J. Mol. Cell. Cardiol. 2016;100:1-8. doi: 10.1016/j.yjmcc.2016.09.008. PubMed PMID: 27642167.
| Year | Degree | Institution |
|---|---|---|
| 2000 | Postdoctoral Training | Institute of Molecular Cardiobiology, The Johns Hopkins University School of Medicine, Baltimore, MD |
| 1997 | PhD | Indiana University |
| 1990 | MS | Nankai University |
| 1987 | BS | Nankai University |
Dr. Chen’s broad research interests involve biochemical, biophysical and cell biological characterizations of several key proteins in the heart. His lab carries out a multi-disciplinary study, ranging from molecular biology, protein-to-protein interactions, intracellular protein distributions and trafficking, to functional studies in cardiac myocytes and whole hearts. Recent published findings from his lab reveal a new research focus to characterize how cardiac membrane proteins are distributed to unique subcellular domains, such as sarcoplasmic reticulum, lateral sarcolemma, transverse tubules, and intercalated discs in cardiac myocytes, performing specific functions, and how misdistribution and dysfunction of these proteins might occur in cardiac diseases. The research will discover and characterize the novel role of these proteins in regulation of cardiac contraction and electrical properties in normal and diseased hearts, with potential for therapeutic intervention.
In collaboration with Dr. Rohan Dharmakumar, Chen's lab investigates dysfunctional mechanisms and possible new treatment strategies in animal models and patients with heart attack.
Active grants.
NIH: 1R01HL169877-01
Project Title: Critical Sorting Steps and Pathways in the Trafficking of Cardiac Sarcoplasmic Reticulum Proteins
AHA Transformational Project Award (23TPA1069000)
Project Title: Critical pathways for distribution of phospholemman and the Na, K-ATPase protein complex in cardiomyocytes
Chen M; Xu D; Wu AZ; Kranias E; Lin SF; Chen PS; Chen Z; 2018 Sep 24
Yin D; Chen M; Yang N; Wu AZ; Xu D; Tsai WC; Yuan Y; Tian Z; Chan YH; Shen C; Chen Z; Lin SF; Weiss JN; Chen PS; Everett TH 4th; Heart rhythm 2018 Jan 8
Yuan Y; Jiang Z; Zhao Y; Tsai WC; Patel J; Chen LS; Shen C; Lin SF; Chen HV; Everett TH 4th; Fishbein MC; Chen Z; Chen PS; Heart rhythm 2017 Nov 27
Wu AZ; Xu D; Yang N; Lin SF; Chen PS; Cala SE; Chen Z; Journal of molecular and cellular cardiology 2016 Sep 15
Chan YH; Tsai WC; Song Z; Ko CY; Qu Z; Weiss JN; Lin SF; Chen PS; Jones LR; Chen Z; Journal of molecular and cellular cardiology 2015 Jan 14
Yu CC; Corr C; Shen C; Shelton R; Yadava M; Rhea I; Straka S; Fishbein MC; Chen Z; Lin SF; Lopshire JC; Chen PS; Circulation. Arrhythmia and electrophysiology 2015 Apr 23
Chen Z; Journal of molecular and cellular cardiology 2014 Sep 3
Lee YS; Chang PC; Hsueh CH; Maruyama M; Park HW; Rhee KS; Hsieh YC; Shen C; Weiss JN; Chen Z; Lin SF; Chen PS; Journal of cardiovascular electrophysiology 2013 May 29
Turker I; Yu CC; Chang PC; Chen Z; Sohma Y; Lin SF; Chen PS; Ai T; PloS one 2013 Jul 29
Shen MJ; Hao-Che Chang; Park HW; George Akingba A; Chang PC; Zheng Zhang; Lin SF; Shen C; Chen LS; Chen Z; Fishbein MC; Chiamvimonvat N; Chen PS; Heart rhythm : the official journal of the Heart Rhythm Society 2013 Jan 26
Hsieh YC; Chang PC; Hsueh CH; Lee YS; Shen C; Weiss JN; Chen Z; Ai T; Lin SF; Chen PS; Circulation. Arrhythmia and electrophysiology 2013 Feb 18
Choi EK; Chang PC; Lee YS; Lin SF; Zhu W; Maruyama M; Fishbein MC; Chen Z; Rubart-von der Lohe M; Field LJ; Chen PS; Circulation journal : official journal of the Japanese Circulation Society 2012 Mar 22
Chen PS; Ogawa M; Maruyama M; Chua SK; Chang PC; Rubart-von der Lohe M; Chen Z; Ai T; Lin SF; Pediatric cardiology 2012 Feb 17
Chen Z; The Biochemical journal 2011 Oct 15
Chua SK; Chang PC; Maruyama M; Turker I; Shinohara T; Shen MJ; Chen Z; Shen C; Rubart-von der Lohe M; Lopshire JC; Ogawa M; Weiss JN; Lin SF; Ai T; Chen PS; Circulation research 2011 Feb 24
Akin BL; Chen Z; Jones LR; The Journal of biological chemistry 2010 Jul 11
Joung B; Lin SF; Chen Z; Antoun PS; Maruyama M; Han S; Piccirillo G; Stucky M; Zipes DP; Chen PS; Das MK; Heart rhythm : the official journal of the Heart Rhythm Society 2009 Sep 16
Chen Z; Akin BL; Jones LR; The Journal of biological chemistry 2009 Nov 30
Joung B; Tang L; Maruyama M; Han S; Chen Z; Stucky M; Jones LR; Fishbein MC; Weiss JN; Chen PS; Lin SF; Circulation 2009 Feb 2
Chen PS; Joung B; Shinohara T; Das M; Chen Z; Lin SF; Circulation journal : official journal of the Japanese Circulation Society 2009 Dec 18
Chen Z; Akin BL; Jones LR; The Journal of biological chemistry 2007 Jun 4
Chen Z; Akin BL; Stokes DL; Jones LR; The Journal of biological chemistry 2006 Mar 22