64030-Madhur, Meena

Meena Madhur, MD, PhD

Associate Professor of Medicine

John B. Hickam Scholar in Medicine

Adjunct Associate Professor of Anatomy, Cell Biology & Physiology

Chief, Division of Clinical Pharmacology

Email
mmadhur@iu.edu
Address
R2 402
MDEP
IN
Indianapolis, IN
PubMed:

Bio

Meena S. Madhur, MD, PhD is the Division Director of Clinical Pharmacology and Associate Professor of Medicine with a secondary appointment in the Department of Anatomy, Cell Biology, and Physiology. Dr. Madhur’s research interests are focused on the interplay between the immune system and hypertension, particularly the renal, vascular, and cardiac complications of hypertension. Her long-term goal is to identify novel diagnostic and therapeutic strategies for this disease. Her early investigations revealed a critical role for the pro-inflammatory cytokine, interleukin 17A (IL-17A), in angiotensin II induced hypertension and vascular dysfunction. Her laboratory has defined pathways by which IL-17A regulates renal sodium transporters and how salt influences T cells in hypertension. Recently her lab has investigated innate immune mechanisms of heart failure with preserved ejection fraction and elucidated how a common genetic polymorphism in LNK/Sh2b3 contributes to hypertension. Dr. Madhur is an active grant reviewer for the National Institutes of Health and American Heart Association. She also serves as Associate Editor of Clinical Science and Guest Editor of Hypertension. She has authored over 50 papers in high impact journals including the Journal of Clinical Investigation (JCI), JCI Insight, Circulation Research, Cardiovascular Research, and Hypertension.

Key Publications

  1. MA Saleh, WG McMaster, J Wu, AE Norlander, SA Funt, SR Thabet, A Kirabo, L Xiao, W Chen, HA Itani, D Michell, T Huan, Y Zhang, S Takaki, J Titze, D Levy, DG Harrison, MS Madhur. “Lymphocyte Adaptor Protein LNK Deficiency Exacerbates Hypertension and End-organ Inflammation.” Journal of Clinical Investigation. 125 (3):1189-1202, 2015 (Epub Feb 9, 2015).
  2. Y Chen, BL Dale, MR Alexander, L Xiao, M Ao, AK Pandey, CD Smart, GK Davis, MS Madhur. “B Cells are Dispensable for the Development of Hypertension.” Cardiovascular Research 117(4):1217-1228, 2021 (Epub July 1, 2020).
  3. MS Madhur?, F Elijovich, MR Alexander, A Pitzer, J Ishimwe, JP Van Beusecum, DM Patrick, CD Smart, TR Kleyman, J Kingery, RN Peck, CL Laffer, A Kirabo? (?co-corresponding authors). “Hypertension: Do Inflammation and Immunity Hold the Key to Solving this Epidemic?” Circulation Research 128 (7): 908-933, 2021 (Epub April 1, 2021).
  4. MR Alexander, S Hank, BL Dale, L Himmel, X Zhong, CD Smart, Y Chen, N Prabakaran, B Tirado, M Ao, D Levy MS Madhur. “A Single Nucleotide Polymorphism in SH2B3 Promotes Hypertension Development and Renal Damage.” Circulation Research 131:731-747, 2022 (Epub September 28, 2022).
  5. CD Smart, DJ Fehrenbach, JW Wassenaar, V Agrawal, NL Fortune, DD Dixon, MA Cottam, AH Hasty, AR Hemnes, AC Doran, DK Gupta, MS Madhur. “Immune profiling of murine cardiac leukocytes identifies Trem2 as a novel mediator of heart failure.” Cardiovascular Research (Epub June 14, 2023).

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