64172-Liaqat, Khurram

Khurram Liaqat, PhD

Postdoctoral Fellow in Medical & Molecular Genetics

Email
kliaqat@iu.edu
Address
IB 252
MMGE
IN
Indianapolis, IN
PubMed:

Bio

Khurram Liaqat, PhD is a Postdoctoral Clinical Genomic Scientist at the Undiagnosed Rare Disease Clinic (URDC). Dr. Liaqat’s primary research interests include rare genetic disorders. 

Dr. Liaqat earned his PhD in Biotechnology (Human Molecular Genetics) and MS in Molecular Biology at Quaid-i-Azam University, Pakistan. During PhD, he spent about two years as a predoctoral fellow at Dr. Suzanne M. Leal’s lab at the Department of Molecular and Human Genetics, Baylor College of Medicine in Houston, TX. He has also completed two years of postdoctoral fellowship at Dr. Leal’s lab at the Center for Statistical Genetics, Department of Neurology, Columbia University Irving Medical Center, New York. During his tenure at Dr. Leal’s lab, he focused on the genetic basis of various rare diseases including skin, bone, neurological, and hearing abnormalities. 

In May 2023, Dr. Liaqat accepted a new role within the Department of Medical and Molecular Genetics as a Postdoctoral Clinical Genomic Scientist with URDC. His primary responsibilities at URDC include the interpretation of genetic sequence variation identified through diagnostic genetics testing or through the research pipelines, primarily using Next Generation Sequencing (WES, WGS, and RNA-seq) under the supervision of URDC directors Dr. Vetrini and Dr. Conboy. Dr. Liaqat is also involved in research projects that report novel gene discoveries, and variant reclassification and contribute to scientific publications.

He is also a recipient of the International Research Support Initiative Program (IRSIP) award from the Higher Education Commission (HEC) of Pakistan. In his free time, he enjoys traveling and spending time with his family in outdoor activities.

Key Publications

  1. Khan FU, Khan H, Ullah K, Nawaz S, Abdullah, Khan MJ, Ahmed S, Ilyas M, Ali A, Ullah I, Sohail A, Hussain S, Ahmad F, Faisal, Sufyan R, Hayat A, Hanif T, Bibi F, Hayat M, Ullah R, Khan IU, Ali RH, Hasni MS, Ali H, Bilal M, Peralta S, Buchert R, Zehri Z, Hassan G, Liaqat K, Zahid M, Shah K, Mikitie O, Haack TB, Ji W, Lakhani SA, Ansar M, Ahmad W. Clinical and genetic investigation of 14 families with various forms of short stature syndromes. Clin Genet. 2024 Sep;106(3):347-353. doi: 10.1111/cge.14550. Epub 2024 May 22. PMID: 38774940.
  2. Bruns R, Liaqat K, Nasir A, Treat K, Murthy VS, Mantcheva L, Torres W, Conboy E, Vetrini F. Undiagnosed rare disease clinic identifies a novel UBE3A variant in two sisters with Angelman syndrome: The end of a diagnostic odyssey. Congenit Anom (Kyoto). 2024 May;64(3):155-160. doi: 10.1111/cga.12566. Epub 2024 Mar 23. PMID: 38520260.
  3. Liaqat K, Treat K, Mantcheva L, Nasir A, Weaver DD, Conboy E, Vetrini F. A case of MBTPS1-related disorder due to compound heterozygous variants in MBTPS1 gene: Genotype-phenotype expansion and the emergence of a novel syndrome. Am J Med Genet A. 2024 May;194(5):e63499. doi: 10.1002/ajmg.a.63499. Epub 2023 Dec 22. PMID: 38135440.
  4. Liaqat K, Treat K, Wilson TE, Conboy E, Vetrini F. Further evidence of involvement of ITSN1 in autosomal dominant neurodevelopmental disorder. Clin Genet. 2024 Apr;105(4):455-456. doi: 10.1111/cge.14497. Epub 2024 Feb 12. PMID: 38346866.
  5. Bilal M, Khan H, Khan MJ, Haack TB, Buchert R, Liaqat K, Ullah K, Ahmed S, Bharadwaj T, Acharya A, Peralta S, Najumuddin, Ali H, Hasni MS, Schrauwen I, Ullah A, Ahmad W, Leal SM. Variants in EFCAB7 underlie nonsyndromic postaxial polydactyly. Eur J Hum Genet. 2023 Nov;31(11):1270-1274. doi: 10.1038/s41431-023-01450-5. Epub 2023 Sep 8. PMID: 37684519; PMCID: PMC10620185.
  6. Liaqat K, Bharadwaj T, Shah K, Nasir A, Acharya A, Khan S, Ullah I, Schrauwen I, Ahmad W, Leal SM. Nonsense variant in a consanguineous family expands the phenotype of KPTN gene-related syndrome to include hearing impairment. Clin Genet. 2023 Oct;104(4):499-501. doi: 10.1111/cge.14390. Epub 2023 Jun 13. PMID: 37311648; PMCID: PMC11041622.
  7. Liaqat K, Hussain S, Acharya A, Nasir A, Bharadwaj T, Ansar M, Basit S, Schrauwen I, Ahmad W, Leal SM. Phenotype Expansion for Atypical Gaucher Disease Due to Homozygous Missense PSAP Variant in a Large Consanguineous Pakistani Family. Genes (Basel). 2022 Apr 9;13(4):662. doi: 10.3390/genes13040662. PMID: 35456468; PMCID: PMC9028228.
  8. Bharadwaj T, Schrauwen I, Rehman S, Liaqat K, Acharya A, Giese APJ, Nouel-Saied LM, Nasir A, Everard JL, Pollock LM, Zhu S, Bamshad MJ, Nickerson DA, Ali RH, Ullah A, Wali A, Ali G, Santos-Cortez RLP, Ahmed ZM, McDermott BM Jr, Ansar M, Riazuddin S, Ahmad W, Leal SM. ADAMTS1, MPDZ, MVD, and SEZ6: candidate genes for autosomal recessive nonsyndromic hearing impairment. Eur J Hum Genet. 2022 Jan;30(1):22-33. doi: 10.1038/s41431-021-00913-x. Epub 2021 Jun 16. PMID: 34135477; PMCID: PMC8738740.
  9. Schrauwen I, Liaqat K, Schatteman I, Bharadwaj T, Nasir A, Acharya A, Ahmad W, Van Camp G, Leal SM. Autosomal Dominantly Inherited GREB1L Variants in Individuals with Profound Sensorineural Hearing Impairment. Genes (Basel). 2020 Jun 23;11(6):687. doi: 10.3390/genes11060687. PMID: 32585897; PMCID: PMC7349314.
  10. Hussain S, Umm-E-Kalsoom, Ullah I, Liaqat K, Nawaz S, Ahmad W. A Novel Missense Variant in the ALX4 Gene Underlies Mild to Severe Frontonasal Dysplasia in a Consanguineous Family. Genet Test Mol Biomarkers. 2020 Apr;24(4):217-223. doi: 10.1089/gtmb.2019.0203. Epub 2020 Mar 27. PMID: 32216639.
  11. Liaqat K, Hussain S, Bilal M, Nasir A, Acharya A, Ali RH, Nawaz S, Umair M, Schrauwen I, Ahmad W, Leal SM. Further evidence of involvement of TMEM132E in autosomal recessive nonsyndromic hearing impairment. J Hum Genet. 2020 Jan;65(2):187-192. doi: 10.1038/s10038-019-0691-4. Epub 2019 Oct 28. Erratum in: J Hum Genet. 2022 Mar;67(3):181. doi: 10.1038/s10038-021-00951-9. PMID: 31656313; PMCID: PMC8216908.
  12. Liaqat K, Schrauwen I, Raza SI, Lee K, Hussain S, Chakchouk I, Nasir A, Acharya A, Abbe I, Umair M, Ansar M, Ullah I, Shah K; University of Washington Center for Mendelian Genomics; Bamshad MJ, Nickerson DA, Ahmad W, Leal SM. Identification of CACNA1D variants associated with sinoatrial node dysfunction and deafness in additional Pakistani families reveals a clinical significance. J Hum Genet. 2019 Feb;64(2):153-160. doi: 10.1038/s10038-018-0542-8. Epub 2018 Nov 30. PMID: 30498240; PMCID: PMC6561484.
  13. Richard EM, Santos-Cortez RLP, Faridi R, Rehman AU, Lee K, Shahzad M, Acharya A, Khan AA, Imtiaz A, Chakchouk I, Takla C, Abbe I, Rafeeq M, Liaqat K, Chaudhry T, Bamshad MJ, Nickerson DA; University of Washington Center for Mendelian Genomics; Schrauwen I, Khan SN, Morell RJ, Zafar S, Ansar M, Ahmed ZM, Ahmad W, Riazuddin S, Friedman TB, Leal SM, Riazuddin S. Global genetic insight contributed by consanguineous Pakistani families segregating hearing loss. Hum Mutat. 2019 Jan;40(1):53-72. doi: 10.1002/humu.23666. Epub 2018 Nov 18. PMID: 30303587; PMCID: PMC6296877.
  14. Liaqat K, Chiu I, Lee K, Chakchouk I, Andrade-Elizondo PB, Santos-Cortez RLP, Hussain S, Nawaz S, Ansar M, Khan MN, Basit S, Schrauwen I, Ahmad W, Leal SM. Novel missense and 3'-UTR splice site variants in LHFPL5 cause autosomal recessive nonsyndromic hearing impairment. J Hum Genet. 2018 Nov;63(11):1099-1107. doi: 10.1038/s10038-018-0502-3. Epub 2018 Sep 3. PMID: 30177809; PMCID: PMC6202120.
  15. Schrauwen I, Chakchouk I, Liaqat K, Jan A, Nasir A, Hussain S, Nickerson DA, Bamshad MJ, Ullah A, Ahmad W, Leal SM. A variant in LMX1A causes autosomal recessive severe-to-profound hearing impairment. Hum Genet. 2018 Jul;137(6-7):471-478. doi: 10.1007/s00439-018-1899-7. Epub 2018 Jul 3. PMID: 29971487; PMCID: PMC6094940.
  16. Nawaz S, Hussain S, Bilal M, Syed N, Liaqat K, Ullah I, Akil AA, Fakhro KA, Ahmad W. A variant in sperm-specific glycolytic enzyme enolase 4 (ENO4) causes human male infertility. J Gene Med. 2024 Jan;26(1):e3583. doi: 10.1002/jgm.3583. Epub 2023 Aug 28. PMID: 37640479.
  17. Bilal M, Haack TB, Buchert R, Peralta S, Uddin N, Ali RH, Liaqat K, Ahmad W. Sequence Variants in MEGF8 and GJA1 Underlying Syndactyly. Mol Syndromol. 2023 Jun;14(3):201-207. doi: 10.1159/000528651. Epub 2023 Feb 1. PMID: 37323198; PMCID: PMC10267519.
  18. Schrauwen I, Ghaffar A, Bharadwaj T, Shah K, Rehman S, Acharya A, Liaqat K, Lin NS, Everard JL, Khan A, Ahmed ZM, Ahmad W, Riazuddin S, Leal SM. Syntaxin 4 is essential for hearing in human and zebrafish. Hum Mol Genet. 2023 Mar 20;32(7):1184-1192. doi: 10.1093/hmg/ddac257. PMID: 36355422; PMCID: PMC10026253.
  19. Raza R, Chhabra G, Bilal M, Ndiaye MA, Liaqat K, Nawaz S, Sgro JY, Rayment I, Ahmad W, Ahmad N. A Homozygous Missense Variant in K25 Underlying Overlapping Phenotype with Woolly Hair and Dental Anomalies. J Invest Dermatol. 2023 Jan;143(1):173-176.e3. doi: 10.1016/j.jid.2022.07.010. Epub 2022 Aug 1. PMID: 35926655.
  20. Adadey SM, Schrauwen I, Aboagye ET, Bharadwaj T, Esoh KK, Basit S, Acharya A, Nouel-Saied LM, Liaqat K, Wonkam-Tingang E, Mowla S, Awandare GA, Ahmad W, Leal SM, Wonkam A. Further confirmation of the association of SLC12A2 with non-syndromic autosomal-dominant hearing impairment. J Hum Genet. 2021 Dec;66(12):1169-1175. doi: 10.1038/s10038-021-00954-6. Epub 2021 Jul 5. PMID: 34226616; PMCID: PMC8612923.
  21. Acharya A, Raza SI, Anwar MZ, Bharadwaj T, Liaqat K, Khokhar MAS, Everard JL, Nasir A; University of Washington Center for Mendelian Genomics; Nickerson DA, Bamshad MJ, Ansar M, Schrauwen I, Ahmad W, Leal SM. Wolfram-like syndrome with bicuspid aortic valve due to a homozygous missense variant in CDK13. J Hum Genet. 2021 Oct;66(10):1009-1018. doi: 10.1038/s10038-021-00922-0. Epub 2021 Apr 21. Erratum in: J Hum Genet. 2021 Oct;66(10):1019. doi: 10.1038/s10038-021-00949-3. PMID: 33879837; PMCID: PMC8472924.
  22. Ullah I, Kakar N, Schrauwen I, Hussain S, Chakchouk I, Liaqat K, Acharya A, Wasif N, Santos-Cortez RLP, Khan S, Aziz A, Lee K, Couthouis J, Horn D, Kragesteen BK, Spielmann M, Thiele H, Nickerson DA, Bamshad MJ, Gitler AD, Ahmad J, Ansar M, Borck G, Ahmad W, Leal SM. Variants in KIAA0825 underlie autosomal recessive postaxial polydactyly. Hum Genet. 2019 Jun;138(6):593-600. doi: 10.1007/s00439-019-02000-0. Epub 2019 Apr 13. PMID: 30982135; PMCID: PMC6724712.
  23. Abdullah, Yousaf M, Azeem Z, Bilal M, Liaqat K, Hussain S, Ahmad F, Ghous T, Ullah A, Ahmad W. Variants in GLI3 Cause Greig Cephalopolysyndactyly Syndrome. Genet Test Mol Biomarkers. 2019 Oct;23(10):744-750. doi:10.1089/gtmb.2019.0071. Epub 2019 Oct 1. PMID: 31573334.
  24. Irfanullah, Zeb A, Shinwari N, Shah K, Gilani SZT, Khan S, Lee KW, Raza SI, Hussain S, Liaqat K, Ahmad W. Molecular and in silico analyses validates pathogenicity of homozygous mutations in the NPR2 gene underlying variable phenotypes of Acromesomelic dysplasia, type Maroteaux. Int J Biochem Cell Biol. 2018 Sep;102:76-86. doi: 10.1016/j.biocel.2018.07.004. Epub 2018 Jul 18. PMID: 30016695.
  25. Schrauwen I, Chakchouk I, Acharya A, Liaqat K, Irfanullah; University of Washington Center for Mendelian Genomics; Nickerson DA, Bamshad MJ, Shah K, Ahmad W, Leal SM. Novel digenic inheritance of PCDH15 and USH1G underlies profound non-syndromic hearing impairment. BMC Med Genet. 2018 Jul 20;19(1):122. doi: 10.1186/s12881-018-0618-5. PMID: 30029624; PMCID: PMC6053831.

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