64183-Liu, Yuan

Yuan Liu, PhD

Assistant Research Professor of Biostatistics & Health Data Science

Email
https://www.liucompbio.com
Phone
317-274-2623
Address
975 W. Walnut St.
IB552
Indianapolis, IN 46202
PubMed:

Bio

Yuan Liu, PhD, is an Assistant Research Professor in the Department of Biostatistics and Health Data Science at Indiana University School of Medicine. He is a computational biologist and bioinformatician whose research integrates multi-omics data, real-world clinical evidence, and interpretable artificial intelligence to investigate disease mechanisms and improve therapeutic development. His research focuses on cancer genomics, immunotherapy efficacy and toxicity, population disparities, neurogenomics in Alzheimer’s disease, regulatory genomics, and targeted protein degradation. Dr. Liu develops and applies statistical and computational methods that connect molecular profiles with clinical outcomes. His work has appeared in Cancer Discovery, Nature Health, Cancer Cell, Nature Communications, Nature Machine Intelligence, Science Advances, Nucleic Acids Research, Cancer Research, and other journals.

Key Publications

  • Liu Y, Luo M, Yang J, et al. “Risk Disparities of Immune-Related Adverse Events in Diverse Racial Groups.” Nature Health. Accepted in principle.
  • Liu Y, Ruppin E, Han L. “Integrating Multi-Dimensional Data to Advance Global Health Equity in Oncology.” Cancer Discovery. 2026;16(4):660–664.
  • Liu Y, et al. “Sex Differences in Toxicities of CAR T-Cell Therapy.” Nature Communications. In press.
  • Liu Y, Han L. “Mapping T Helper Cell Targets with Deep Learning: AI in Immunology.” Nature Machine Intelligence. 2025.
  • Chen C, et al. “Comprehensive Characterization of the Transcriptional Landscape in Alzheimer’s Disease Brains.” Science Advances. 2025;11(1):eadn1927.
  • Liu Y, et al. “Expanding PROTACtable Genome Universe of E3 Ligases.” Nature Communications. 2023;14:6509.
  • Jing Y, Liu Y, Li Q, et al. “Expression of Chimeric Antigen Receptor Therapy Targets Detected by Single-Cell Sequencing of Normal Cells May Contribute to Off-Tumor Toxicity.” Cancer Cell. 2021;39:1558–1559.  

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