6622-Wen, Qiuting

Qiuting Wen, PhD

Assistant Professor of Radiology & Imaging Sciences

Address
GH 4100

Indianapolis, IN 46202
PubMed:

Bio

Dr. Qiuting Wen (pronounced chiu-ting) obtained her Ph.D. from the UCSF-UC Berkeley Joint Ph.D. Program in Bioengineering, where she developed a keen interest in MRI techniques and their translational applications. After completing her Ph.D., she joined Indiana University, focusing on advanced diffusion MRI. Dr. Wen developed dynamic Diffusion-Weighted Imaging (dynDWI) for measuring paravascular cerebrospinal fluid (pCSF) dynamics, a key element in the brain's waste clearance system (the glymphatic system).

Her research focuses on how dysfunctional CSF dynamics contribute to aging, Alzheimer's disease, and CSF disorders like normal pressure hydrocephalus. Dr. Wen’s lab integrates multiple imaging modalities, including dynDWI, fMRI, and phase-contrast imaging, to study CSF-hemodynamic coupling and its physiological drivers.

Lab website: https://sites.google.com/view/wenlab/home



Key Publications

  1. Wright, A.M., Wu, YC., Yang, HC. Tong Y*., Wen Q*. Coupled pulsatile vascular and paravascular fluid dynamics in the human brain. Fluids Barriers CNS 21, 71 (2024). https://doi.org/10.1186/s12987-024-00572-2
  2. Wright AM, Wu YC, Feng L, Wen Q*. Diffusion magnetic resonance imaging of cerebrospinal fluid dynamics: Current techniques and future advancements. NMR Biomed. 2024 May 7:e5162. doi: 10.1002/nbm.5162. Epub ahead of print. PMID: 38715420.
  3. Wright AM, Wu YC, Chen NK, Wen Q*. Exploring Radial Asymmetry in MR Diffusion Tensor Imaging and Its Impact on the Interpretation of Glymphatic Mechanisms. J Magn Reson Imaging. 2023 Dec 29. doi: 10.1002/jmri.29203. Epub ahead of print. PMID: 38156600.
  4. Wen Q*, Wright A, Tong Y, Zhao Y, Risacher SL, Saykin AJ, Wu YC, Limaye K, Riley K. Paravascular fluid dynamics reveal arterial stiffness assessed using dynamic diffusion-weighted imaging. NMR Biomed. 2023 Oct 5:e5048. doi: 10.1002/nbm.5048. Epub ahead of print. PMID: 37798964.
  5. Wen Q, Wang H, Haacke EM, Jiang Q, Hu J. Contribution of Direct Cerebral Vascular Transport in Brain Substance Clearance. Aging Dis. 2023 Aug 13. doi: 10.14336/AD.2023.0426. Epub ahead of print. PMID: 37611901.
  6. Wen Q*, Tong Y, Zhou X, Dzemidzic M, Ho CY, Wu YC. Assessing Pulsatile Waveforms of Paravascular Cerebrospinal Fluid Dynamics within the Glymphatic Pathways using Dynamic Diffusion-weighted Imaging (dDWI). Neuroimage, 2022.
  7. Shahid SS, Wen Q, Risacher SL, Farlow MR, Unverzagt FW, Apostolova LG, Foroud TM, Zetterberg H, Blennow K, Saykin AJ, Wu YC. Hippocampal-subfield microstructures and their relation to plasma biomarkers in Alzheimer's disease. Brain.  2022 Jun 30;145(6):2149-2160. 
  8. Hall Z, Chien B, Risacher SL, Saykin AJ, Wu YC, Wen Q*. Tau deposition and structural connectivity demonstrate differential association patterns with neurocognitive tests. Brain Imaging and Behavior 2021 Sep 17 (Cover article)
  9. Wen Q*, Risacher SL, Xie L, Li J, Harezlak J, Tallman E, Farlow MR, Unverzagt FW, Gao S, Apostolova LG, Saykin AJ, and Wu YC. Tau-related white-matter alterations along spatially selective pathways. Neuroimage. 2021 Feb 1;226:117560.
  10. Wen Q*, Feng L, Zhou K, Wu Y-C. Rapid golden-angle diffusion-weighted propeller MRI for simultaneous assessment of ADC and IVIM. Neuroimage. 2020 Dec;223:117327
  11. Wen Q, Mustafi SM, Harezlak J, Li J, Risacher SL, West JD, Tallman E, Farlow MR, Unverzagt FW, Apostolova LG, Saykin AJ, and Wu YC. White-matter alterations in early-stage Alzheimer’s disease: A tract-specific study. Alzheimers Dement (Amst). 2019 Dec; 11: 576–587
  12. Wen Q, Kodiweera C, Dale BM, Shivraman G, Wu Y-C. Rotating single-shot acquisition (RoSA) with composite reconstruction for fast high-resolution diffusion imaging. Magnetic Resonance in Medicine 2018 Jan,79(1):264-275
  13. Wen Q, Kelley D, Banerjee S, Xu D, Lupo JM, Hess C, Nelson SJ. Clinically feasible NODDI characterization of brain tumor using an optimized multiband EPI at 7T. Neuroimage Clin. 2015, 9: 291–299.
  14. Wen Q, Jalilian L, Lupo JM, Molinaro AM., Chang SM, Clarke J, Prados M, Nelson SJ. Comparison of ADC metrics and their association with outcome for patients with newly diagnosed glioblastoma being treated with radiation therapy, temozolomide, erlotinib and bevacizumab, J Neurooncol. 2015 Jan,121(2):331-9.
  15. Wen Q, Jalilian L, Lupo JM, Li Y, Roy R, Molinaro AM, Chang SM, Prados M, Butowski N, Clarke J, Nelson SJ. Association between diffusion and clinical outcome varies with treatment regimen for patients with newly diagnosed glioblastoma. Transl Oncol. 2015 Dec,8(6):446-55.

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