67374-Sayed, Marawan

Marawan A. Sayed, PhD

Postdoctoral Fellow in Neurology

Address
GH 4700
NEUR
IN
Indianapolis, IN

Bio

Translational neuroscientist and pharmacologist with extensive experience in preclinical and in vivo models of neurological and systemic disease, biomarker discovery, and mechanism-of-action studies. Strong record of interdisciplinary collaboration spanning academia and translational research environments.

Key Publications

1-Seddiek, H., Hanna, M., Hamoud, A. E. M., Elbaset, M. A., Akabawy, A. M. A., Kotb, M. Z., & Khalifa, M. M. (2025). Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment. Sci. Rep., 15(1), 4485. https://doi.org/10.1038/s41598-025-87628-x. 

Role: Designed and executed in vivo neuropharmacology experiments and contributed to mechanistic analysis of iron handling, ferritinophagy, and neuroprotection endpoints.

2- Hanna, M., Akabawy, A. M. A., Khalifa, M. M., Elbaset, M. A., Imam, R. A., & Seddiek, H. (2025). Intracellular iron accumulation throughout the progression of sepsis influences the phenotype and function of activated macrophages in renal tissue damage. Front. Physiol., 16. https://doi.org/10.3389/fphys.2025.1430946

Role: Contributed to experimental design, renal tissue analysis, and mechanistic interpretation of iron-dependent macrophage dysfunction during sepsis progression.

3- Elbaset, M. A., Afifi, S. M., Esatbeyoglu, T., Abdelrahman, S. S., & Saleh, D. O. (2024). Neuroprotective Effects of Trimetazidine against Cisplatin-Induced Peripheral Neuropathy: Involvement of AMPK-Mediated PI3K/mTOR, Nrf2, and NF-κB Signaling Axes. Oxidative Medicine and Cellular Longevity, 2024(1). https://doi.org/10.1155/2024/6612009.

Role: Led in vivo efficacy studies and contributed to signaling pathway analysis (AMPK-PI3K/mTOR, Nrf2, NF-κB) supporting mechanism-of-action conclusions.

4- Mahmoud, N. S., Elbaset, M. A., Mohawed, O. A. M., & Ahmed, H. H. (2024). Trimetazidine attenuates neuroinflammation via TLR4/NF-KB pathway inhibition in lipopolysaccharides-induced dementia in rats. Journal of Applied Pharmaceutical Science. https://doi.org/10.7324/JAPS.2024.166458.

Role: Conducted in vivo neuroinflammation experiments and contributed to pathway-focused analysis of TLR4/NF-κB signaling modulation.

5- Salem, E. M., Dawaba, H. M., Elbaset, M. A., Gad, S., & Hassan, T. H. (2024). Optimizing bioavailability and antihypertensive activity of Carvedilol cubosomes using D-optimal design: Comparative analysis of Cremophor RH 40 and Polyvinyl alcohol as secondary stabilizers. Journal of Drug Delivery Science and Technology, 97, 105817. https://doi.org/10.1016/j.jddst.2024.105817.

Role: Contributed to pharmacodynamic evaluation and in vivo efficacy assessment supporting formulation optimization.

8- S.A.E. Bashandy, A.M.A. El-Seidy, F.A.A. Ibrahim, S.S. Abdelrahman, S.A. Abdelmottaleb Moussa, M.A. ElBaset, Zinc nanoparticles ameliorated obesity-induced cardiovascular disease: role of metabolic syndrome and iron overload, Sci. Rep. 13 (2023) 16010. https://doi.org/10.1038/s41598-023-42550-y.

Role: Conducted in vivo cardiovascular pharmacology studies and contributed to metabolic and iron-overload mechanistic analyses.

9- N.F. Abdelkader, S.M. Ibrahim, P.E. Moustafa, M.A. Elbaset, Inosine mitigated diabetic peripheral neuropathy via modulating GLO1/AGEs/RAGE/NF-κB/Nrf2 and TGF-β/PKC/TRPV1 signaling pathways, Biomed. Pharmacother. 145 (2022) 112395. https://doi.org/10.1016/j.biopha.2021.112395.

Role: Performed in vivo neuropathy assessments and contributed to multi-pathway signaling analysis and data interpretation.

10- N.F. Abdelkader, M.A. Elbaset, P.E. Moustafa, S.M. Ibrahim, Empagliflozin mitigates type 2 diabetes-associated peripheral neuropathy: a glucose-independent effect through AMPK. signaling, Arch. Pharm. Res. 45 (2022) 475–493. https://doi.org/10.1007/s12272-022-01391-5.

Role: Led in vivo efficacy studies and contributed to mechanistic evaluation of glucose-independent AMPK-mediated neuroprotection.

11- M. Hanna, H. Seddiek, B.E. Aboulhoda, G.N.B. Morcos, A.M.A. Akabawy, M.A. Elbaset, A.A. Ibrahim, M.M. Khalifa, I.M. Khalifah, M.S. Fadel, T. Shoukry, Synergistic cardioprotective effects of melatonin and deferoxamine through the improvement of ferritinophagy in doxorubicin-induced acute cardiotoxicity, Front. Physiol. 13 (2022). https://doi.org/10.3389/fphys.2022.1050598.

Role: Executed in vivo cardioprotection studies and contributed to ferritinophagy-focused mechanistic investigations.

11- N. Sharawy, A.A.A. Imam, B.E. Aboulhoda, M.M. Khalifa, G.N.B. Morcos, W.A. Abd Algaleel, P.E. Moustafa, M.A. Abdelbaset, T. Shoukry, Iron dyshomeostasis and time-course changes in iron-uptake systems and ferritin level in relation to pro-inflammatory microglia polarization in sepsis-induced encephalopathy, Front. Physiol. 13 (2022). https://doi.org/10.3389/fphys.2022.953206.

Role: Contributed to experimental design, neuroinflammation assessments, and interpretation of iron–microglia interaction dynamics.

 

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