69266-Noor, Sohail

Sohail Noor, PhD

Assistant Professor of Neurological Surgery

Address
GH 5100
SNEU
IN
Indianapolis, IN
PubMed:

Bio

Dr. Sohail Noor joined the Department of Neurological Surgery in February 2025 as a tenure-track assistant professor. He holds dual appointments at both the School of Medicine and IU Health. His research interests encompass neurophysiology, brain mapping, neural signal processing and neuromodulation mechanisms and technology. At IU Health, he is involved in intraoperative neurophysiology for brain mapping during deep brain stimulation surgeries.

Dr. Noor's doctoral research at the University of Calgary focused on investigating the mechanisms of deep brain stimulation in both animal models and human patients, using electrophysiology and imaging. He conducted his postdoctoral research at Case Western Reserve University and Duke University, where he developed computational models to understand and localize field potentials recorded from Parkinson’s disease patients and investigated neural dynamics in response to selective brain stimulation in depression patients.

Dr. Noor is dedicated to advancing neuroscience and particularly neuromodulation by addressing key challenges to improve the health of millions suffering from medication-resistant neurological disorders. He employs both invasive and non-invasive electrophysiology, anatomical and functional imaging, and computational modeling to achieve this goal.

Passionate about educating the next generation of scientists, Dr. Noor aims to foster intellectual curiosity, critical thinking, and practical problem-solving skills among his students. With significant mentoring experience, he has supervised numerous undergraduate and graduate students from both neuroscience and engineering backgrounds.

Dr. Noor's research has been published in respected journals such as PNAS, Brain Stimulation, and NeuroImage. Additionally, he serves as a reviewer for various journals, including Brain Stimulation, Journal of Neural Engineering, and IEEE Transactions on Biomedical Engineering.

Key Publications

1.     Chen H*, Noor MS*, Bingham CS, and McIntyre CC. 2024. Optimization of an anatomically and electrically detailed subthalamic nucleus neuron model. Journal of Neurophysiology 132: 136–146. doi:10.1152/jn.00287.2023

2.     Noor MS, Steina AK, and McIntyre CC. 2024. Dissecting Deep Brain Stimulation Evoked Neural Activity in the Basal Ganglia. Neurotherapeutics 21(3): e00356. doi:10.1016/j.neurot.2024.e00356

3.     Seas A*, Noor MS*, Choi KS, Veerakumar A, Obatusin M, Dahill-Fuchel J, Tiruvadi V, Xu E, Riva-Posse P, Rozell CJ, Mayberg HS, McIntyre CC, Waters AC, Howell B. 2024. Subcallosal cingulate deep brain stimulation evokes two distinct cortical responses via differential white matter activation. Proceedings of the National Academy of Sciences 121(14):e2314918121. doi:10.1073/pnas.2314918121

4.     Noor MS, Howell B, McIntyre CC. 2023. Role of the volume conductor on simulations of local field potential recordings from deep brain stimulation electrodes. PloS One 18(11): e0294512. doi:10.1371/journal.pone.0294512

5.     Noor MS, McIntyre CC. 2021. Biophysical characterization of local field potential recordings from directional deep brain stimulation electrodes. Clinical Neurophysiology 132(6): 1321-9. doi:10.1016/j.clinph.2021.01.027

6.     Noor MS, Yu L, Murari K, Kiss ZHT. 2020. Neurovascular coupling during deep brain stimulation. Brain Stimulation 13(3): 916-27. doi:10.1016/j.brs.2020.03.005

7.     Noor MS, Murari K, McCracken CB, Kiss ZHT. 2016. Spatiotemporal dynamics of cortical perfusion in response to thalamic deep brain stimulation. NeuroImage 126:131-9. doi:10.1016/j.neuroimage.2015.11.017

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