Justus Huelse, PhD
Assistant Research Professor of Pediatrics
- Address
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FH 320
PEDC
IN
Indianapolis, IN - PubMed:
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Bio
Dr. Huelse is an Assistant Research Professor, working at the intersection of cancer biology and translational oncology research. During his PhD and postdoctoral training at Emory University, he focused on TAM family kinases (TYRO3, AXL, MERTK) as direct and immunotherapeutic targets in acute leukemia, including the preclinical development of small molecule inhibitors and molecular degraders. His research seeks to understand how aberrant TAM kinase signaling promotes leukemia progression while simultaneously suppressing anti-tumor immunity, and to translate these mechanistic insights into new therapeutic strategies with potential for clinical application.
| Year | Degree | Institution |
|---|---|---|
| 2026 | Postdoctoral Training | Emory University |
| 2023 | PhD | Emory University |
| 2014 | M.Sc. | University of Copenhagen |
| 2011 | BSC | University of Konstanz |
UNC9426, a Potent and Orally Bioavailable TYRO3-Specific Inhibitor.
Kong Deyu, Yang Xiangbo, Judd Samantha, Yan Dan, Springborn Stephanie, Stashko Michael A, Kidwell Adam, Huelse Justus M, Kireev Dmitri, Graham Douglas K, DeRyckere Deborah, Branchford Brian, Wang Xiaodong Journal of medicinal chemistry 2025 Mar 27
Kong Deyu, Yang Xiangbo, Judd Samantha, Yan Dan, Springborn Stephanie, Stashko Michael A, Kidwell Adam, Huelse Justus M, Kireev Dmitri, Graham Douglas K, DeRyckere Deborah, Branchford Brian, Wang Xiaodong Journal of medicinal chemistry 2025 Mar 27
Exploiting structural variability in the kinase back-pocket to modulate polypharmacology of TAM inhibitors.
Hopkins Megan D, Zhang Dehui, Chen Zhilong, McIver Andrew L, Huelse Justus M, Mahajan Jyoti P, Lyu Kaikai, Yang Xiangbo, Stashko Michael A, Smith Brittany, Yeung Tsz Y, Earp H Shelton, Frye Stephen V, DeRyckere Deborah, Kireev Dmitri, Graham Douglas K, Wang Xiaodong European journal of medicinal chemistry 2025 Jun 05
Hopkins Megan D, Zhang Dehui, Chen Zhilong, McIver Andrew L, Huelse Justus M, Mahajan Jyoti P, Lyu Kaikai, Yang Xiangbo, Stashko Michael A, Smith Brittany, Yeung Tsz Y, Earp H Shelton, Frye Stephen V, DeRyckere Deborah, Kireev Dmitri, Graham Douglas K, Wang Xiaodong European journal of medicinal chemistry 2025 Jun 05
Prospects of current AXL-targeting therapies in early phase cancer trials.
Yim Juhye, Hope Chloe, Huelse Justus M, Graham Douglas K Expert opinion on investigational drugs 2025 Jun
Yim Juhye, Hope Chloe, Huelse Justus M, Graham Douglas K Expert opinion on investigational drugs 2025 Jun
Discovery of Novel TYRO3/MERTK Dual Inhibitors.
Kong Deyu, Zhao Jichen, Huang Daowei, Stashko Michael A, Yan Dan, Ding Ransheng, Guduru Shiva K R, Zhou Yubai, Kania Catherine E, Shelton Earp H, Frye Stephen V, Huelse Justus M, Kireev Dmitri, DeRyckere Deborah, Graham Douglas K, Wang Xiaodong Journal of medicinal chemistry 2025 Apr 24
Kong Deyu, Zhao Jichen, Huang Daowei, Stashko Michael A, Yan Dan, Ding Ransheng, Guduru Shiva K R, Zhou Yubai, Kania Catherine E, Shelton Earp H, Frye Stephen V, Huelse Justus M, Kireev Dmitri, DeRyckere Deborah, Graham Douglas K, Wang Xiaodong Journal of medicinal chemistry 2025 Apr 24
MERTK Inhibition as a Targeted Novel Cancer Therapy.
Tanim K M, Holtzhausen Alisha, Thapa Aashis, Huelse Justus M, Graham Douglas K, Earp H Shelton International journal of molecular sciences 2024 Jul 12
Tanim K M, Holtzhausen Alisha, Thapa Aashis, Huelse Justus M, Graham Douglas K, Earp H Shelton International journal of molecular sciences 2024 Jul 12
MERTK inhibition selectively activates a DC - T-cell axis to provide anti-leukemia immunity.
Huelse Justus M, Bhasin Swati S, Jacobsen Kristen M, Yim Juhye, Thomas Beena E, Branella Gianna M, Bakhtiari Mojtaba, Chimenti Madison L, Baxter Travon A, Raikar Sunil S, Wang Xiaodong, Frye Stephen V, Henry Curtis J, Earp H Shelton, Bhasin Manoj, DeRyckere Deborah, Graham Douglas K Leukemia 2024 Dec
Huelse Justus M, Bhasin Swati S, Jacobsen Kristen M, Yim Juhye, Thomas Beena E, Branella Gianna M, Bakhtiari Mojtaba, Chimenti Madison L, Baxter Travon A, Raikar Sunil S, Wang Xiaodong, Frye Stephen V, Henry Curtis J, Earp H Shelton, Bhasin Manoj, DeRyckere Deborah, Graham Douglas K Leukemia 2024 Dec
TAM family kinases as therapeutic targets at the interface of cancer and immunity.
DeRyckere Deborah, Huelse Justus M, Earp H Shelton, Graham Douglas K Nature reviews. Clinical oncology 2023 Nov
DeRyckere Deborah, Huelse Justus M, Earp H Shelton, Graham Douglas K Nature reviews. Clinical oncology 2023 Nov
MERTK activation drives osimertinib resistance in EGFR-mutant non-small cell lung cancer.
Yan Dan, Huelse Justus M, Kireev Dmitri, Tan Zikang, Chen Luxiao, Goyal Subir, Wang Xiaodong, Frye Stephen V, Behera Madhusmita, Schneider Frank, Ramalingam Suresh S, Owonikoko Taofeek, Earp H Shelton, DeRyckere Deborah, Graham Douglas K The Journal of clinical investigation 2022 Aug 01
Yan Dan, Huelse Justus M, Kireev Dmitri, Tan Zikang, Chen Luxiao, Goyal Subir, Wang Xiaodong, Frye Stephen V, Behera Madhusmita, Schneider Frank, Ramalingam Suresh S, Owonikoko Taofeek, Earp H Shelton, DeRyckere Deborah, Graham Douglas K The Journal of clinical investigation 2022 Aug 01
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