Sisters hugging each other

The Gift of Quality Time

IU neurologist-oncologist Na Tosha Gatson wants her brain cancer patients to live longer. More than that, she wants them to live well. Kathy Lane is a perfect example.

KATHY LANE RECALLS being alone in her San Diego home and getting ready for church. Recalls feeling ill with the symptoms of a nasty stomach flu. Remembers it getting worse — so bad she felt compelled to seek help from a neighbor. Vaguely, she remembers a stranger coming to her aid.

Her sister, Kristy, remembers much more.

Back in Indianapolis, she had received an alert on her smartphone from Kathy’s video doorbell. She assumed it was a delivery dropped on the doorstep. Instead, the camera showed her sister, standing barefoot and in a bathrobe as rain fell. Someone was trying to help, but Kathy was clearly confused and in distress, struggling for words, managing only one.

“Help.”

What followed — an ambulance ride to a hospital, Kristy and their mother arriving in San Diego, a battery of medical tests and the next few weeks — were all lost to Kathy’s memory. But Kristy remembers. Especially what the doctors said: Her sister had Stage 4 lung cancer. Tumors had spread to Kathy’s brain — 18 when they stopped counting — and they were the reason for her delirium at the door.

Yet the final gut punch came weeks later. When Kathy couldn’t tolerate radiation treatments, doctors said she had months to live, maybe weeks. There was nothing to do but seek hospice care. “That was heartbreaking,” Kristy said. That was Spring 2024.

Instead of giving up, the family brought Kathy home to Indiana and sought care at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center. More than a year and a half later, Kathy Lane, 66, is still here, still living with her sister in Indianapolis, and grateful for each day.

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For her continued presence, Kathy Lane praises God. But somewhere down the line, she also credits the care from a phalanx of physicians at IU, most notably a neurologist-oncologist who focuses on giving patients facing a brain cancer diagnosis a precious gift: quality living.

Na Tosha N. Gatson, MD, PhD, a native of Fort Wayne who trained at The Ohio State University and MD Anderson Cancer Center, came to IU in March 2024 — about the same time Kathy fell ill. Neurology drew Gatson because, “of all the organs in the human body, the brain is the one most responsible for maintaining the essence of what it means to be human.” Cancer, she said, erodes that humanity.

Gatson treats patients whose tumors originate in the brain or, like Kathy Lane, originate elsewhere in the body. It’s a field where patient survival rates are among the lowest in the cancer realm, and Gatson takes a clearheaded view.

“I understand my job is not to simply maintain their survival, but to improve their quality of living” she said. “Too often, as physicians, we make the mistake of believing we can save lives. We cannot. Instead, we must focus on ensuring that our treatments are not worse than the disease and that we can help them live as well as possible for as long as possible.”

Gatson is the director of IU’s new Center for Neuro-Oncology, leading physicians and researchers whose specialties span medical and surgical neurology and cancer care for all ages. While IU has displayed strength in basic research of neuro-oncology, its resumé in clinical trials is less robust. That’s where Gatson, having served as principal investigator on nine brain tumor trials and a co-investigator on others, and leading patent-pending brain tumor imaging research, comes in.

She partners with neurosurgical colleagues to offer unique brain tumor therapies including brachytherapy, where radioactive seeds are implanted directly within the tumor cavity to deliver high-dose radiation to the cancer cells at the time of surgery. She has partnered with the largest European brain tumor consortium to validate a method to use MRI images to more quickly determine when brain cancer therapies are no longer effective. She’s also founded and leads Neuro-oncology of Women, a subfield dedicated to increasing awareness around how brain tumors affect women at various hormonal phases across their lifespan.

Gatson has considerable experience treating patients whose cancer has infiltrated the cerebrospinal fluid — the liquid that surrounds and cushions the brain and spinal cord. This condition, leptomeningeal carcinomatosis, or LMC, was the most immediate threat to Kathy Lane, more than the tumors in her brain and lungs. Left untreated, it can kill within weeks. Even with treatment, survival is typically no more than six months.

Gatson Headshot

Too often, as physicians, we make the mistake of believing we can save lives. We cannot. Instead, we must focus on ensuring that our treatments are not worse than the disease and that we can help them live as well as possible for as long as possible.

Na Tosha N. Gatson, MD, PhD

Director, IU Center for Neuro-Oncology

At IU, Lane was first treated by oncologist Rohan Maniar, MD, who soon invited Gatson to help with her case. Since then, the two have been tag-teaming to balance out the impacts of treatment. Gatson focuses on the brain, Maniar on the body.

For the LMC, Gatson prescribed a plan that called for neurosurgeons to place a port, called an Ommaya reservoir, on Kathy’s skull allowing for the injection of chemotherapy drugs into the brain cerebrospinal fluid. Samples can also be drawn later to monitor the presence of cancer, response to treatment, and identify targets for next steps. Gatson has partnered with six other medical oncologists at the cancer center to perform over 65 such procedures in the last year.

So far, it’s working. Kathy battles fatigue and a lack of appetite, but just four months ago she took a break from treatment and traveled back to San Diego to visit friends and even try her hand at pickle ball. These days, she’s attending her mother’s church, engaging with Kristy’s church family and rejoicing in the time with her sister, who shared a bed with her as a child, a room as a teen and a lifelong bond. “I’m just grateful,” Kathy said. “I’m excited to get up in the morning.”

In a family of seven siblings, three brothers survive, but Kathy and Kristy are the only sisters left. And they’re not ready to part. As Kristy puts it, “Kathy’s always been the wind beneath my wings.”

This spring, on Mother’s Day, their mother died. Kathy was there for her final year, and at the end. It was one of the blessings of the extra time. And it spared their mother the grief of having to bury another child.

For that, Kathy says she’s grateful to God, and thankful for the research that made her treatment possible. And Gatson? Kathy describes her as a “godsend” who has given her hope from the moment she first saw her. “I love Dr. Gatson being in my corner,” she said. “It makes you want to just keep trying, keep pressing, keep hoping.”

To help advance neuro-oncology research at IU Simon Comprehensive Cancer Center, please contact Amber Kleopfer Senseny at akleopfe@iu.edu.