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A Multicenter, Open-Label, Randomized, Bupivacaine-Controlled Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Aged 0 to Less Than 6 ...
This Phase 1, multicenter, open-label, randomized, bupivacaine-controlled study is designed to evaluate the pharmacokinetics (PK) and safety of EXPAREL vs. bupivacaine HCl for postsurgical analgesia in pediatric subjects aged 0 ...
Cleopattra: Effects of Nnc6019-0001 Versus Placebo on Cardiovascular Outcomes in Participants with Transthyretin Amyloid Cardiomyopathy
This study will find out if a new medicine called NNC6019-0001 can help reduce the risk of heart-related death and illness in participants with a condition called transthyretin amyloid cardiomyopathy ...
Sc2i-Woundx-001-Woundx Pilot Trial: Proof of Concept Feasibility for the Clinical Operations of Woundx in Aiding Clinicians Identify Wounds That Are Ready for Surgical Closure
The purpose of this research is to evaluate the overall use of the WounDx medical device in a clinical setting, such as a hospital. The WounDx device is experimental and ...
Alnylam ALN-APP-001: Phase I, Placebo-Controlled Trial of ALN-APP in Participants with Early-Onset Alzheimer’S Disease
Who is Eligible Ages 18+ Must have had symptoms of Alzheimer’s disease prior to age 65 Diagnosis of Alzheimer’s disease Must be able to complete MRI Must be able to tolerate lumbar puncture No history of ...
A Phase 2, Two-Stage, Randomized, Double-Blind, Placebo-Controlled, Multiple-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of Rls-0071 in Newborns with Moderate ...
Hypoxic-ischemic encephalopathy (HIE) affects approximately 4,000 to 12,000 persons annually in the United States. Mortality from HIE has been reported up to 60%, with at least 25% of survivors left ...
Efficacy and Safety of Nnc0487-0111 Compared to Placebo on Morbidity and Mortality in People with Heart Failure with Preserved or Mildly Reduced Ejection Fraction ...
This study is being done to look at the safety and effect of NNC0487-0111 in people with Heart Failure with preserved Ejection Fraction (HFpEF) or Heart Failure with mildly reduced ...
Identification of Serum and Urine Biomarkers of Type 1 Diabetes
The purpose of this study is to identify biomarkers (small molecules in the blood) that can predict those people at risk of developing Type 1 diabetes. THIS STUDY IS ENROLLING BY ...
The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action
Obesity prevalence in persons with T1D has increased, which further complicates managementd risk for complications. The proposed study is relevant to public health because it helps us understand the role ...
A Multicenter, Open-Label, Phase 1/2, Dose-Escalation and Subsequent Safety Extension Study of Subcutaneous KK8123 in Adult Patients with X-Linked Hypophosphatemia
The purpose of this study is to test the safety and effectiveness of an investigational drug called KK8123 in adults with X-linked hypophosphatemia. THIS STUDY IS ENROLLING BY INVITATION ONLY - ...
Phase 1 Imaging Study of 68Ga-R12961 in Advanced Solid Tumors
The goals of this study are:To describe the safety of 68Ga-R12961To describe preliminary imaging efficacy of 68Ga-R12961 in participants with advanced solid tumors.To compare 68Ga-R12961 positron emission tomography/computed tomography (PET/CT) ...