The Center for Neuro-Oncology is a collaboration across multiple disciplines to provide personalized comprehensive care to patients with tumors of the nervous system and a leading destination center in the state of Indiana and beyond. The center provides excellence in clinical care, research and education for central/peripheral nervous systems tumors and cancer neurology. It’s the mission of the center to deliver optimal patient outcomes, perform cutting-edge research, and educate medical professionals, patients, and caregivers. Patient experience is enhanced through innovation in clinical care, education and research in a state-of-the-art environment.
Vision
The center prioritizes the physical, psychological, cognitive, and spiritual care needs of our patients, and deliver the same high-level support to patients and their caregivers anywhere within the IU Health system. Excellence in neuro-oncology is indispensable to cancer care.
Clinical Programs
The IU Health Neuro-Oncology Brain and Spine Metastases Multi-Disciplinary Clinic was designed to allow patients to meet their Neuro-Oncology, Neurosurgery, and Radiation Oncology providers during a single educational visit. This allows the patient and their caregiver(s) an opportunity to discuss their diagnosis, treatment options, their healthcare goals and values, and any important next steps.
Our goals are to achieve durable local control of CNS disease, ensuring it is neither disabling nor life-threatening, while maintaining a low complication rate of 3% or less for serious or treatment-delaying complications. We aim to get patients back on systemic therapy as quickly as possible and develop a structured pathway to ensure seamless continuity of care for brain metastases patients.
The Neuro-Oncology Program at Riley Children's Health provides nationally ranked care to children with brain and spinal cord tumors.
Aiming to provide a great patient experience by having a complete multidisciplinary team working together to consolidate care and make it easier for patients. Our focus is on improving the structure of patient care, addressing their total needs, and continuously enhancing the patient experience.
Education
The Neurosurgical Oncology/Skull Base Fellowship in the Department of Neurological Surgery offers a well-rounded experience in managing complex brain tumors. This one-year fellowship opportunity offers participation in operative management of aneurysms and arteriovenous malformations and therefore encompasses a broad range of complex cranial procedures.
The two-year, ACGME-accredited Neurotology Fellowship is available every other year through the Department of Otolaryngology—Head and Neck Surgery. The fellow will master surgical approach during the first year and progress to tumor removal and cranial nerve conservation surgery during the second year.
The one-year Rhinology and Endoscopic Skull Base Surgery Fellowship in the Department of Otolaryngology—Head and Neck Surgery focuses on developing skills in assessment, treatment strategies and surgical techniques used in the management of complex rhinologic and neuro-rhinologic conditions. The fellowship will provide an experience that will prepare the trainee to enter into a career in academic rhinology.
Clinical Research
Neur-Nuvation SIGMA - Phase III multicenter study evaluating Safusidenib Erbumine in patients with IDH1-mutant glioma.
PI: Kathryn Nevel
MSK AbbVie - Phase Ib trial evaluating ABBV-637 or ABBV-155 in combination with ERAS-801 for glioblastoma with EGFR amplification.
PI: Kathryn Nevel
SonoCloud SC9-GBM-03 - Phase III Randomized study evaluating SonoCloud-9 plus carboplatin versus standard therapy for recurrent glioblastoma.
PI: Kathryn Nevel
NEUR-JAZZ-JZP3507-202 - Phase 2 Study to Investigate Efficacy, Safety, Tolerability, and Pharmacokinetics of JZP3507 (ONC206) in Adults With Recurrent Grade 2 or 3 Meningioma
PI: Na Tosha N. Gatson
Sample Collection to Assess Physioxia in Brain Tumors - Sample collection study focused on assessing physioxia in brain tumors.
PI: Angela Richardson
Agios AG881-C-004 - A Phase 3, Multicenter, Randomized, Double-blind, Placebo-Controlled Study of AG-881 in Subjects With Residual or Recurrent Grade 2 Glioma with an IDH1 or IDH2 Mutation
PI: Kathryn Nevel
NEUR-ECOG-ACRIN-EAF151 - Phase II DSC-MRI in Measuring Relative Cerebral Blood Volume for Early Response to Bevacizumab in Patients with Recurrent Glioblastoma
PI: Kathryn Nevel
IVY-P3-24-021 - A Phase 3, Open-label, Randomized 2-arm Study Comparing the Clinical Efficacy and Safety of Niraparib with Temozolomide in Adult Participants With Newly diagnosed, MGMT Unmethylated Glioblastoma
PI: Kathryn Nevel
Springworks MEK-NF1-201 - A Phase 2b Trial of the MEK 1/2 Inhibitor (MEKi) PD-0325901 in Adult and Pediatric Patients with Neurofibromatosis Type 1 (NF1)-Associated Inoperable Plexiform Neurofibromas (PNs) that are Causing Significant Morbidity
PI: Kathryn Nevel
SNEU-GTMEDICAL-NEW-METS - Phase 3 Randomized Controlled Trial of Post-Surgical Stereotactic Radiotherapy (SRT) versus Surgically Targeted Radiation Therapy (STaRT) with Gamma Tile for Treatment of Newly Diagnosed Metastatic Brain Tumors
PI: Angela Richardson
Multicenter Observational Study of GammaTile™ Surgically Targeted Radiation Therapy (STaRT) in Intracranial Brain Neoplasms - Observational study evaluating GammaTile™ surgically targeted radiation therapy in intracranial brain neoplasms.
PI: Mitesh Shah
BRIDGES Trial with GammaTile® - Phase 3 clinical study evaluating the use of GammaTile® in upfront treatment of ndGBM.
Co PI: Angela Richardson
Co PI: Na Tosha N. Gatson
SNEU-GTMEDICAL-GTM-103 - Phase 4 Feasibility Study of Resection and GammaTile Followed by Concomitant External Beam Radiation Therapy (EBRT) and Temozolomide (TMZ) and Adjuvant TMZ in Newly Diagnosed Glioblastoma (GBM)
PI: Mitesh Shah
SNEU-STRYKER-SONOPET - An Observational Study: Surgeon experience using the Novel Pulse Control Setting on Sonopet including video demonstration of use.
PI: Mitesh Shah
SNEU-OSU-SPINE-TUMORS - A Prospective Registry of Spine Cancer Patients Undergoing Surgical decompression followed by Radiation Therapy for Spine Tumors
PI: Matthew Pease
Long-term Outcomes of Skull Base Repair for Spontaneous CSF Leaks - Outcomes study evaluating long-term results after skull base repair for spontaneous CSF leaks. Pituitary and Vestibular Schwannoma. PI: Rick Nelson
Registry of Adenomas of the Pituitary and Related Disorders (RAPID) - Registry study focused on pituitary adenomas and related disorders. PI: João Paulo Almeida
Multiomic Landscape of Vestibular Schwannomas - Translational research study focused on the multiomic profile of vestibular schwannomas. PI: Rick Nelson
CTO-NRG-CC009 - Phase III Trial of Stereotactic Radiosurgery (SRS) versus Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for Brain Metastases from Small Cell Lung Cancer
PI: Kevin Shiue
IUSCC-0605 - A pilot phase 2 study evaluating dose de-escalation in whole brain radiation therapy with simultaneous integrated boost for patients with brain metastases
PI: Kevin Shiue
RAON-IIR-IUSCC-0710 - Radiosurgery Dose Reduction for Brain Metastases on Immunotherapy (RADREMI): A Prospective Pilot Study
PI: Kevin Shiue
PHO-SICKKIDS-BIOBANK-REGISTRY - The Rare Brain Tumor Consortium Registry and Biobank
PI: Alex Lion
PHO-IIR-IUSCCC-0797 - Assessing Household Material Hardship in Children with Central Nervous System (CNS) Tumors.
PI: Alex Lion
PHO-IU-SHIH-FATIGUE - Assessing Fatigue Experienced by Pediatric Patients with Intracranial Neoplasms
PI: Alex Lion
PHO-SHIH-NWC-HEADSTART4 - Newly diagnosed children (less than 10 years old) with medulloblastoma and other central nervous system embryonal tumors: Clinical and molecular risk-tailored intensive and compressed induction chemotherapy followed by consolidation with either single cycle (low risk patients) or randomization (high risk patients) to either single-cycle or three tandem cycles of marrow-ablative chemotherapy with autologous hematopoietic progenitor cell rescue
PI: Alex Lion
PHO-PNOC-PNOC021 - Phase I trial evaluating trametinib and everolimus in pediatric and young adult patients with recurrent low-grade and high-grade gliomas.
PI: Brian Weiss
PHO-PNOC-PNOC022 - A Combination Therapy Trial using an Adaptive Platform Design for Children and Young Adults with Diffuse Midline Gliomas (DMGs) including Diffuse Intrinsic Pontine Gliomas (DIPGs) at Initial Diagnosis, Post-Radiation Therapy and at Time of Progression.
PI: Brian Weiss
PHO-UCSF-PNOC029 - Phase II Combination Therapy Trial using an Adaptive Platform Design for Children and Young Adults with Diffuse Midline Gliomas (DMGs) including Diffuse Intrinsic Pontine Gliomas (DIPGs) at Initial Diagnosis, Post-Radiation Therapy and at Time of Progression
PI: Brian Weiss
PHO-PNOC-PNOCO30 - A Registry Study for Children with Atypical Teratoid Rhabdoid Tumor (ATRT)
PI: Brian Weiss
PNOC031: Protocol for Embryonal Tumor With Multilayered Rosettes (ETMR)
PI: Brian Weiss
PHO-UCSF-PNOC-COMP - A Protocol for Children and Young Adults Diagnosed with a Central Nervous System (CNS) Tumor to Assess Cognitive, Quality of Life (QOL), and Comprehensive Effects of Therapies
PI: Brian Weiss
SNEU-IIR-BRAINSTEM-BIOPSY - The Safety and Diagnostic Utilization of Brainstem Biopsy in the Pediatric Patient Population with Brainstem Neoplasm
PI: Jignesh Tailor
SNEU-UC-ATPC - Advancing Treatment for Pediatric Craniopharyngioma: Prospective Pilot Study Identifying Clinically Relevant Biological Targets for Medical Therapy
PI: Jignesh Tailor
Indiana Neurosciences Biorepository at Riley - Biorepository infrastructure supporting translational neuroscience and Neuro-Oncology research
PI: Jignesh Tailor
Pediatric Brain Tissue Donation Program at Riley - Pediatric brain tissue donation program supporting future translational research
PI: Jignesh Tailor
Interested in participating in a clinical study?
Contact the Neuroscience Institute's clinical trials team at neuroct@iu.edu to reach out and learn more about a trial.