Researchers at the Indiana University School of Medicine Department of Anesthesia contribute regularly to the creation of new knowledge, understanding and treatments surrounding various specialties in anesthesia and pain management.
Explore our latest research articles and academic contributions, and check back regularly to stay informed on the latest advancements in the field.
El Jammal R, Tfaily A, Cochran AG, Nguyen T, Miller D, El Ayoubi N, Soluoku T, White FA, Obeid M. The long-term effects of limbic non-convulsive status epilepticus in peri-adolescent rats. Epilepsy Behav. 2024 Oct 29;161:110086. doi: 10.1016/j.yebeh.2024.110086. Epub ahead of print. PMID: 39476704.
Miller J, Jacobs S, Koppes W, Minella F, Porta F, White FA, Lovelace JA. Development of Machine Learning Algorithms Using EEG Data to Detect the Presence of Chronic Pain. medRxiv [Preprint]. 2024 Sep 19:2024.09.18.24313903. doi: 10.1101/2024.09.18.24313903. PMID: 39371148; PMCID: PMC11451669.
Talley S, Nguyen T, Van Ye L, Valiauga R, DeCarlo J, Mustafa J, Cook B, White FA, Campbell EM. Characterization of age-associated inflammasome activation reveals tissue specific differences in transcriptional and post-translational inflammatory responses. Immun Ageing. 2024 Sep 10;21(1):60. doi: 10.1186/s12979-024-00462-z. PMID: 39256821; PMCID: PMC11384696.
Charouf D, Miller D, Haddad L, White FA, Boustany RM, Obeid M. High Diagnostic Yield and Clinical Utility of Next-Generation Sequencing in Children with Epilepsy and Neurodevelopmental Delays: A Retrospective Study. Int J Mol Sci. 2024 Sep 6;25(17):9645. doi: 10.3390/ijms25179645. PMID: 39273593; PMCID: PMC11395515.
Haltom JP, Martin AS. Ethical and practical considerations of pediatric refusal in clinical anesthesia: An educational review. Paediatr Anaesth. 2024 Aug;34(8):689-696. doi: 10.1111/pan.14921. Epub 2024 May 13. PMID: 38738763.
Boyer TJ, Mitchell SA. Thank you artificial intelligence: Evidence-based just-in-time training via a large language model. Am J Surg. 2024 Aug;234:26-27. doi: 10.1016/j.amjsurg.2024.04.007. Epub 2024 Apr 8. PMID: 38609743.
Lahiri DK, Maloney B, Wang R, White FA, Sambamurti K, Greig NH, Counts SE. The seeds of its regulation: Natural antisense transcripts as single-gene control switches in neurodegenerative disorders. Ageing Res Rev. 2024 Aug;99:102336. doi: 10.1016/j.arr.2024.102336. Epub 2024 May 11. PMID: 38740308; PMCID: PMC11492926.
Smith AB, Jung M, O'Donnell D, White FA, Pressler SJ. Pain, Return to Community Status, and 90-Day Mortality Among Hospitalized Patients With Heart Failure. J Cardiovasc Nurs. 2024 Jul 10. doi: 10.1097/JCN.0000000000001114. Epub ahead of print. PMID: 38915135.
Barboi C, Stapelfeldt WH. Mortality following noncardiac surgery assessed by the Saint Louis University Score (SLUScore) for hypotension: a retrospective observational cohort study. Br J Anaesth. 2024 Jul;133(1):33-41. doi: 10.1016/j.bja.2024.03.039. Epub 2024 May 3. PMID: 38702236; PMCID: PMC11213987.
Joo P, Kim M, Kish B, Nair VV, Tong Y, Liu Z, O'Brien ARW, Harte SE, Harris RE, Lee U, Wang Y. Brain network hypersensitivity underlies pain crises in sickle cell disease. Sci Rep. 2024 Mar 27;14(1):7315. doi: 10.1038/s41598-024-57473-5. PMID: 38538687; PMCID: PMC10973361.
Fogel EL, Easler JJ, Yuan Y, Yadav D, Conwell DL, Vege SS, Han SY, Park W, Patrick V, White FA. Safety, Tolerability, and Dose-Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis: Protocol for a Phase 1 Clinical Trial to Determine Safety and Identify Side Effects. JMIR Res Protoc. 2024 Mar 7;13:e50513. doi: 10.2196/50513. PMID: 38451604; PMCID: PMC10958339.
Bao X, Kumar SS, Shah NJ, Penning D, Weinstein M, Malhotra G, Rose S, Drover D, Pennington MW, Domino K, Meng L, Treggiari M, Clavijo C, Wagener G, Chitilian H, Maheshwari K; HPI Study Team. AcumenTM hypotension prediction index guidance for prevention and treatment of hypotension in noncardiac surgery: a prospective, single-arm, multicenter trial. Perioper Med (Lond). 2024 Mar 4;13(1):13. doi: 10.1186/s13741-024-00369-9. PMID: 38439069; PMCID: PMC10913612.
Meng L, Rasmussen M, Meng DM, White FA, Wu LJ. Integrated Feedforward and Feedback Mechanisms in Neurovascular Coupling. Anesth Analg. 2024 Feb 12. doi: 10.1213/ANE.0000000000006891. Epub ahead of print. PMID: 38345932.
Solanki K, Bezsonov E, Orekhov A, Parihar SP, Vaja S, White FA, Obukhov AG, Baig MS. Effect of reactive oxygen, nitrogen, and sulfur species on signaling pathways in atherosclerosis. Vascul Pharmacol. 2024 Mar;154:107282. doi: 10.1016/j.vph.2024.107282. Epub 2024 Feb 5. PMID: 38325566.
Meng L, Rasmussen M, Meng DM, White FA, Wu LJ. Integrated Feedforward and Feedback Mechanisms in Neurovascular Coupling. Anesth Analg. 2024 Feb 12. doi: 10.1213/ANE.0000000000006891. Epub ahead of print. PMID: 38345932.
Li W, Pucka AQ, Debats C, Reyes BA, Syed F, O'Brien ARW, Mehta R, Manchanda N, Jacob SA, Hardesty BM, Greist A, Harte SE, Harris RE, Yu Q, Wang Y. Inflammation and autoimmunity are interrelated in patients with sickle cell disease at a steady-state condition: implications for vaso-occlusive crisis, pain, and sensory sensitivity. Front Immunol. 2024 Feb 1;15:1288187. doi: 10.3389/fimmu.2024.1288187. PMID: 38361924; PMCID: PMC10867278.
Nazzal MK, Morris AJ, Parker RS, White FA, Natoli RM, Fehrenbacher JC, Kacena MA. Using AI to Write a Review Article Examining the Role of the Nervous System on Skeletal Homeostasis and Fracture Healing. Curr Osteoporos Rep. 2024 Feb;22(1):217-221. doi: 10.1007/s11914-023-00854-y. Epub 2024 Jan 13. PMID: 38217755; PMCID: PMC10912134.
Nazzal MK, Morris AJ, Parker RS, White FA, Natoli RM, Kacena MA, Fehrenbacher JC. Do Not Lose Your Nerve, Be Callus: Insights Into Neural Regulation of Fracture Healing. Curr Osteoporos Rep. 2024 Feb;22(1):182-192. doi: 10.1007/s11914-023-00850-2. Epub 2024 Jan 31. PMID: 38294715; PMCID: PMC10912323.
Morris AJ, Parker RS, Nazzal MK, Natoli RM, Fehrenbacher JC, Kacena MA, White FA. Cracking the Code: The Role of Peripheral Nervous System Signaling in Fracture Repair. Curr Osteoporos Rep. 2024 Feb;22(1):193-204. doi: 10.1007/s11914-023-00846-y. Epub 2024 Jan 18. PMID: 38236511; PMCID: PMC10912155.
Huang C, Chen Y, Kou M, Wang X, Luo W, Zhang Y, Guo Y, Huang X, Meng L, Xiao Y. Evaluation of a modified ultrasound-assisted technique for mid-thoracic epidural placement: a prospective observational study. BMC Anesthesiol. 2024 Jan 19;24(1):31. doi: 10.1186/s12871-024-02415-x. PMID: 38243195; PMCID: PMC10797981.
Yu CJ, Rigueiro F, Backfish-White K, Cartwright J, Moore C, Mitchell SA, Boyer T. Cricothyrotomy in Acute Upper Gastrointestinal Bleed: A Difficult Airway Simulation Case for Anesthesiology Residents. MedEdPORTAL. 2024 Jan 16;20:11378. doi: 10.15766/mep_2374-8265.11378. PMID: 38230362; PMCID: PMC10789914.
Wang Y, Wang DD, Pucka AQ, O'Brien ARW, Harte SE, Harris RE. Differential clinical characteristics across traditional Chinese medicine (TCM) Syndromes in patients with sickle cell disease. Front Pain Res (Lausanne). 2024 Jan 5;4:1233293. doi: 10.3389/fpain.2023.1233293. PMID: 38249565; PMCID: PMC10796810.
Ravindranath S, Ranganath YS, Backfish-White K, Wolfe J, Adhikary S. The Role of Regional Anaesthesia and Acute Pain Services in Value-Based Healthcare. Turk J Anaesthesiol Reanim. 2023 Dec 27;51(6):450-458. doi: 10.4274/TJAR.2023.231478. PMID: 38149004; PMCID: PMC10758672.
Smith JA, Nguyen T, Davis BC, Lahiri DK, Hato T, Obukhov AG, White FA. Propranolol treatment during repetitive mild traumatic brain injuries induces transcriptomic changes in the bone marrow of mice. Front Neurosci. 2023 Sep 12;17:1219941. doi: 10.3389/fnins.2023.1219941. PMID: 37817806; PMCID: PMC10561692.
Nguyen T, Nguyen N, Cochran AG, Smith JA, Al-Juboori M, Brumett A, Saxena S, Talley S, Campbell EM, Obukhov AG, White FA. Repeated closed-head mild traumatic brain injury-induced inflammation is associated with nociceptive sensitization. J Neuroinflammation. 2023 Aug 27;20(1):196. doi: 10.1186/s12974-023-02871-1. PMID: 37635235; PMCID: PMC10464478.
Naugle KM, Nguyen T, Smith JA, Saxe J, White FA. Racial Differences in Head Pain and Other Pain-Related Outcomes After Mild Traumatic Brain Injury. J Neurotrauma. 2023 Aug;40(15-16):1671-1683. doi: 10.1089/neu.2022.0415. Epub 2023 Feb 24. PMID: 36565020; PMCID: PMC10494907.
McNeil-Masuka J, Boyer TJ. Insensible Fluid Loss. 2023 Jul 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31334939.
Boyer TJ, Mitchell SA. Utilization of Embedded Simulation Personnel in Medical Simulation. 2023 Jul 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 32965965.
Smith JA, Nguyen T, Karnik S, Davis BC, Al-Juboori MH, Kacena MA, Obukhov AG, White FA. Repeated mild traumatic brain injury in mice elicits long term innate immune cell alterations in blood, spleen, and brain. J Neuroimmunol. 2023 Jul 15;380:578106. doi: 10.1016/j.jneuroim.2023.578106. Epub 2023 May 16. PMID: 37245410; PMCID: PMC10330602.
Abbasi RK, Cossu AE, Tanner B, Castelluccio P, Hamilton M, Brown J, Herrmann J. Liposomal bupivacaine reduces opioid requirements following Ravitch repair for pectus excavatum. J Anaesthesiol Clin Pharmacol. 2023 Jul-Sep;39(3):392-396. doi: 10.4103/joacp.joacp_336_21. Epub 2022 Oct 14. PMID: 38025581; PMCID: PMC10661631.
Zhang W, Wang M, Lv W, White FA, Chen X, Obukhov AG. Long-Term Treatment with Gadopentetic Acid or Gadodiamide Increases TRPC5 Expression and Decreases Adriamycin Nuclear Accumulation in Breast Cancer Cells. Cells. 2023 May 3;12(9):1304. doi: 10.3390/cells12091304. PMID: 37174704; PMCID: PMC10177392.
Boyer TJ, Kritzmire SM. Neonatal Anesthesia. 2023 Apr 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 31082074.
Ludwig N, Demaree IS, Yamada C, Nusbaum A, Nichols FC, White FA, Movila A, Obukhov AG. Dihydroceramides Derived from Bacteroidetes Species Sensitize TRPV1 Channels. Int J Mol Sci. 2023 Jan 3;24(1):877. doi: 10.3390/ijms24010877. PMID: 36614317; PMCID: PMC9821624