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Arrhythmia and Electrophysiology Clinical Trials

Older woman with auburn hair outside with her adult daughter. Investigators of the Krannert Cardiovascular Research Center are continuing to advance electrophysiology through research at the molecular and cellular level, incorporating novel biomedical engineering approaches to contribute new findings regarding arrhythmogenesis in adults. They examine the root causes of arrhythmias and cardiac arrest and test potential therapies to treat cardiac arrest and arrhythmias.

Cardiac arrest happens when the heart unexpectedly stops pumping and is caused by arrhythmias. When cardiac arrest occurs, the blood stops flowing to the brain and other vital organs. Some of these arrhythmias can consist of irregular and rapid heart rhythms, which can include disorganized electrical signals, heart palpitations, shortness of breath and fatigue.

Atrial Fibrillation or AFib, is among the most common of arrhythmias, and affects more than 2 million people in the United States. The risk of getting AFib increases as one ages, especially if they are 65 years of age or more. 

Current Clinical Trials

Left vs. Left RCT Study: Cardiac Resynchronization Therapy Using His/Left Bundle Branch Pacing vs. Biventricular Pacing with a Left Ventricular Epicardial Lead in Patients with Heart Failure (HF) with Left Ventricular Ejection Fraction (LVEF) 

Objective: Investigators aim to prospectively evaluate the comparative effectiveness His or Left bundle branch pacing (His/LBBP) versus biventricular pacing (BiVP) in patients with heart failure due to left ventricular systolic dysfunction and with either a wide QRS (≥130 ms) or with/anticipated >40% pacing who are receiving current standard heart failure pharmacological therapy by assessing all cause death and heart failure hospitalization at the end of the study.

PI: Antonio J. Navarrette, MD 

NCT No. NCT05650658

Status: New 

 

Sympathetic Nerve Activity and Cardiovascular Events

Objective: The purpose of this study is to test the hypothesis that skin sympathetic nerve activity (SKNA) can be used as a biomarker for physiological events including predicting neurological recovery during therapeutic hypothermia for cardiac arrest, and to risk stratify patients for recurrence of atrial fibrillation following catheter ablation.

PI: Thomas H. Everett, PhD

Status: Enrolling By Invitation 

NCT No. N/A

 

Email the clinical research team to learn more and participate

Featured Publications

Automatic Detection and Characterization of Autonomic Dysreflexia Using Multi-Modal Non-Invasive Sensing and Neural Networks

Shruthi Suresh, Thomas H Everett, Riyi Shi, Bradley S Duerstock; Neurotrauma Reports, Vol. 3, No 1. 2022, Nov. 10.

PRINCIPAL INVESTIGATOR
4919-Everett, Thomas

Thomas H. Everett, PhD

Associate Professor of Medicine

Read Bio

PRINCIPAL INVESTIGATOR
Antonio Navarrette, MD

Antonio J. Navarrette, MD

Cardiologist, Indiana University Health

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