Cardiopulmonary Clinical Trials 

Cardiopulmonary research explores the molecular underpinnings of heart and lung disorders utilizing precision medicine tools and techniques. This includes understanding the mechanisms and genetics of pulmonary arterial hypertension, a condition that affects the blood vessels in the lungs, and sickle cell cardiomyopathy, which could lead to sudden death.

Pulmonary arterial hypertension largely affects women (4:1 female to male ratio) with survival rates estimated to be around 50% at 7 years despite the addition of multiple therapies.

Studies are aimed at new molecular pathways that are discovered from genetic studies in patients and translating them as targets for novel therapies.

LEVEL STUDY: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Pulmonary Hypertension Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction (PH-HFpEF)

Objective: The study will evaluate the efficacy and safety of chronic oral levosimendan compared with placebo in preserved left ventricular ejection fraction (PH-HFpEF) subjects as measured by the change in a 6-minute walk distance. Levosimendan and its prolonged active metabolite, OR-1896, have been shown to have favorable hemodynamic effects in subjects with PH and right HF.

PI: Ankit A. Desai, MD

Status: Now Recruiting

NCT No. NCT05983250

SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics
Sangam S, Sun X, Shwantes-An T, Yegambaram M, Lu Q, Shi Y, Cook T, Fisher A, Frump AL, Coleman A, Sun Y, Liang S, Crawford H, Lutz KA, Maun AD, Paucilio MW, Karnes JH, Chaudhary KR, Stewart DJ, Langlais P, Jain M, Alotaibi M, Lahm T, Jin Y, Gu H, Tang H, Nichols WC, Black SM, Desai AA. Co-senior authors. In Press. American Journal of Respiratory and Critical Care Medicine. 3/2023.

IL-18 mediates sickle cell cardiomyopathy and ventricular arrhythmias.
Gupta A, Fei YD, Kim TY, Xie A, Batai K, Greener I, Tang H, Ciftci-Yilmaz S, Juneman E, Indik JH, Shi G, Christensen J, Gupta G, Hillery C, Kansal MM, Parikh DS, Zhou T, Yuan JX, Kanthi Y, Bronk P, Koren G, Kittles R, Duarte JD, Garcia JGN, Machado RF, Dudley SC, Choi BR, Desai AA. Blood. 2020 Nov 12. PMID:33181835.

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