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Cardiooncology Clinical Trials

Five diverse young professionals walk outside.Cancer treatments such as chemotherapy, targeted therapies, radiation and immunotherapy can cause heart problems, known as cardiotoxicity. This can lead to conditions including cardiomyopathy, coronary artery disease, arrhythmias and valve disease, either during or long after treatment. Cardiooncology specialists monitor heart health at three stages: before, during and after cancer treatment, especially in patients with existing cardiovascular risks like hypertension or diabetes.

Preventing heart disease involves managing cardiometabolic health through awareness of risk factors, blood pressure and cholesterol monitoring, diabetes management and exercise. Patients are encouraged to maintain follow-up care to catch early signs of cardiovascular disease (CVD) and adjust their lifestyles to reduce these risks.

Clinical research in cardiooncology plays a crucial role in understanding and mitigating the cardiovascular risks associated with cancer treatments. By enrolling patients in clinical trials, researchers can study the effects of anti-cancer therapies on the heart, develop strategies to prevent severe side effects like myocarditis, and improve overall patient care. These studies help refine treatment protocols and provide new insights into balancing effective cancer treatment with cardiovascular health, ultimately enhancing long-term outcomes for cancer survivors.

Current Clinical Trials

Abatacept in Immune Checkpoint Inhibitor Myocarditis (ATRIUM)

Objective: The purpose of this study is to test whether abatacept, as compared to placebo, is associated with a reduction in major adverse cardiac events (MACE) among participants hospitalized with myocarditis secondary to an immune checkpoint inhibitor.

PI: Suparna C. Clasen, MD MSCE 

Status: Enrolling By Invitation

NCT No. NCT05335928

 

Atherosclerotic cardiovascular disease management using coronary CT angiography in Prostate Cancer Patients on Androgen Depravation Therapy

Objective: This randomized pilot study of Coronary CT Angiography (CCTA) evaluates coronary atherosclerosis versus the usual care in patients with prostate cancer who are either planning to begin or are currently taking androgen deprivation therapy.

PI: Suparna C. Clasen, MD MSCE

Status: Now Enrolling

NCT No. NCT05879913

 

Registry: Cardiometabolic Risk in African American Patients with Prostate Cancer

Objective: To identify impactful risk factors including socioeconomic factors associated with cardiovascular disease (CVD) in black men with prostate cancer (PC) and to (ii) test the impact of those risk factors in a retrospective study in PC patients for development of a risk model.

PI: Abhishek Khemka, MD

Status: Registry

NCT No. N/A

 

Registry: Cardiovascular Outcomes Among Patients Receiving Chimeric Antigen Receptors T-Cell Therapy

Objective: The primary objective of this study is to determine the incidence and characterize the nature of cardiovascular adverse events occurring following CAR T-cell therapy, including arrhythmia, cardiac ischemia, myocarditis, and heart failure, the therapeutic modalities used to treat these cardiovascular events.

PI: Suparna C. Clasen, MD MSCE

Status: Registry

 

Detection of late subclinical cardiovascular disease in testicular cancer survivors exposed to high-dose platinum-chemotherapy and bone marrow transplant

Objective: The primary objective of this study is to compare levels of the Atherosclerotic cardiovascular disease (ASCVD) lipid biomarkers (Lp(a), VLDL, and apoB) among testicular cancer survivors (TCS) exposed to platinum-based chemotherapy and bone marrow transplant compared with TCS cured with surgical resection and surveillance.

PI: Suparna C. Clasen, MD MSCE

Status: Now Enrolling

NCT No. NCT05611307

 

Personalized medical treatment of coronary atherosclerosis in prostate cancer patients guided by plaque assessment with quantitative coronary CT angiography.

Objective: The primary objective of this study is to use quantitative Coronary CT Angiography (CCTA) to define the prevalence of atherosclerotic cardiovascular disease (ASCVD) in men with prostate cancer receiving ADT, and to characterize gaps in treatment of ASCVD and its risk factors by identifying patients with atherosclerosis who are not receiving optimal medical treatment.

PI: Suparna C. Clasen, MD MSCE

Status: Now Enrolling

NCT No. NCT05879913

 

Radiation-induced Coronary Microvascular Disease in Racially Diverse Breast Cancer Patients

Objective: The primary object of this study is to compare the magnitude and characteristics of subclinical microvascular disease using cardiac PET/CT to ascertain the myocardial perfusion imaging, myocardial blood flow, and myocardial blood flow reserve amongst a diverse group of breast cancer patients undergoing RT.

PI: Suparna C. Clasen, MD MSCE

Status: Enrollment Not Yet Open

 

Email the clinical research team to learn more and participate

Featured Publications

Cardiovascular disease in thymic cancer patients
Abhishek Khemka, Suparna C. Clasen, Patrick J. Loehrer, Anna R. Roberts, Lilian Golzarri-Arroyo, Sunil S. Badve, Subha V. Raman, Siu L. Hui, Titus K. L. Schleyer; Frontiers in Cardiovascular Medicine. 09 September 2024, Volume 11 - 2024; https://doi.org/10.3389/fcvm.2024.1393631

Cardiovascular Risks in Testicular Cancer: Assessment, Prevention, and Treatment
Suparna C. Clasen, Chunkin Fung, Howard D. Sesso, Lois B. Travis; Current Oncology Reports. 2023, Mar 3

How to Manage Cisplatin-Based Chemotherapy-Related Cardiovascular Disease in Patients With Testicular Cancer
Sindhuja Kadambi, Suparna C. Clasen, and Chunkit Fung; JACC CardioOncology. 2022, Sept 4 (3) 409-412

Cisplatin, environmental metals, and cardiovascular disease: an urgent need to understand underlying mechanisms
Suparna C. Clasen, Paul C. Dinh Jr., Lifang Hou, Chunkit Fung, Howard D. Sesso, Lois B. Travis. Cardio-Oncology (London, England), 2021, Oct 10

Principal Investigator
44716-Clasen, Suparna

Suparna C. Clasen, MD, MSCE

Assistant Professor of Clinical Medicine

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Principal Investigator
40-Khemka, Abhishek

Abhishek Khemka, MD

Associate Professor of Clinical Medicine

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Investigators

Clinical Investigator
Brijesh Patel, DO

Brijesh J. Patel, DO

Cardiologist and Cardiooncologist, Indiana University Health

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