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Cardiovascular Quality and Population Health Research

Disparities exist in nearly every aspect of health, including quality of health care, access to care, utilization of health care and health outcomes. Despite notable improvements in the overall health of the United States during the past two decades, there continues to be striking disparities in the burden of illness and death experienced across populations by race, ethnicity, sex, age, rurality, zip code and neighborhood.

Cardiovascular disease, the leading cause of death, further highlights the urgency of addressing these disparities. A disproportionate death rate and disease prevalence of heart failure remains among multiple racial and ethnic groups and female patients. For example, according to a paper published in the July 2022 issue of Circulation, while age-adjusted mortality rates declined among both Black and white adults, Black women and men encountered higher cardiovascular mortality rates than white persons between 1999 and 2019. Furthermore, younger Black women are more than twice as likely to experience premature death from cardiovascular causes than white women, and Black women and men living in rural areas experience the highest cardiovascular mortality rates nationwide.

The Cardiovascular Quality and Population Health Research program is working to understand the impact of the various facets of disparities on cardiovascular disease, develop strategies to address them and implement best practices.

From population studies to implementation science studies

The Cardiovascular Quality and Population Health program, led by Khadijah Breathett, MD, MS, FACC, FAHA, FHFSA, is focused on addressing health care delivery systems to improve quality, access to care and outcomes across populations. Studies conducted vary from randomized controlled trials and observational population studies to implementation science studies and community interventions that are designed to reduce disparities through implementing best practices within the health care delivery system.

Principal Investigator
61331-Breathett, Khadijah

Khadijah Breathett, MD, MS

Executive Director, Krannert Cardiovascular Research Center
Associate Professor of Medicine

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Khadijah Breathett, MD, speaks at a podium at the Institute for Peace.

Select Current Studies

Seeking Objectivity in Allocation of Advanced Heart Failure Therapies Trial (SOCIAL HF), NCT05390411

This multi-site randomized controlled pragmatic cluster trial/Type 2 hybrid implementation science study will assess real-world effectiveness and implementation of an evidence-based multi-component strategy to improve allocation rate of life-saving advanced heart failure therapies, heart transplants and ventricular assist devices. This study proposes to implement evidence-based strategies that reduce unequal and unethical decision-making towards patients, replace subjective evaluations with objective criteria, and improve group dynamics in a randomized cluster trial.

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TRAJECTORY Study: Changing Generational Trajectory of Cardiovascular Disease with the Adult Children and Grandchildren of the Women’s Health Initiative Study

This study extends the Women’s Health Initiative to a sample of adult children and grandchildren of participants currently enrolled in the Women’s Health Initiative and will provide strategies to address generational social determinants of health to inform the next trial and iteration of the Women’s Health Initiative. Current American families and their future generations are at greater risk of developing cardiovascular disease, and we do not fully understand how social determinants of health contribute to future cardiovascular disease across family generations. Moreover, strategies to correct related factors have been underpromoted. Understanding these important non-medical contributors to health is key to changing the trajectory of cardiovascular disease across family generations in both women and men.

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Research Team

portrait of dalancee trabue

Dalancee Trabue, MS

Research Coordinator

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Krystiauna Cole, MS

Research Technician

Ryan Yee, MS

Ryan Yee, MS

Statistician

 

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Shannon Knapp, PhD

Statistician

Faculty

52146-Ilonze, Onyedika

Onyedika Ilonze, M.D., MPH

Assistant Professor of Clinical Medicine

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Fellows

62107-Johnson, Adedoyin

Adedoyin Johnson, MD, PhD

PGY 4
Tulane University School of Medicine

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Janina Quintero Bisono, MD, MS

Ohio State University Cardiology Fellow

Residents

67605-Navarro Martinez, Daniel

Daniel Navarro Martinez, MD

NIH Stimulating Access to Research in Residency Scholar

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67600-Garcia, Alan

Alan Garcia, MD

Internal Medicine, PGY 2
Universidad Autónoma de Guadalajara

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64607-Fretz, Thomas

Thomas J. Fretz, MD

Internal Medicine, PGY 3
State University Of New York At Buffalo School Of Medicine

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Ikeoluwapo Bolakale-Rufai, MD

Northwestern University resident

Undergraduate and High School Research Interns

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Sanjana Adig

 


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Yonathon Bezza

 


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Arya Goel

 


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Elizabeth Mar

 


   

External Collaborators

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Natalie Pool, PhD, RN

Assistant Professor, University of Northern Colorado School of Nursing

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Megan Hebdon, PhD, DNP, RN, NP-C

University of Utah