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Medicinal and Analytical Chemistry

Services

  • Participate in your grant and/or provide a letter of support

  • Provide lab space, instrumentation and training for molecule design, synthesis and analysis.

  • Small molecules as well as peptide design, synthesis, and analysis by LCQTOF/NMR.

  • Drug, metabolites qualification and quantification by LCQTOF.

  • Intact Protein characterization and covalent inhibitor drug discovery.

Featured Instruments

Agilent 1290 LC -6545 QTOF

  • LC/high accurate mass analysis up to four decimals for small molecules, peptides and oligonucleotides

  • LC/MS for proteins and modified proteins (covalent inhibitors discovery)

  • LC/MS/MS analysis: targeted and untargeted

black and white lab instrument

Compound Libraries

Total collection: ~220,000 compounds

Diversity-Oriented Small Molecules

LOPAC 1280: Includes 1,280 known drugs and bioactives, covering all major target classes, including CPCRs and kinases

Microsource Spectrum: Comprises 2,400 US and international drugs, natural products and their derivatives, and reported bioactives (non-drug enzyme inhibitors, receptor blockers, membrane active compounds, and cellular toxins) that have not made it to clinical trials

AnalytiCon MEGx: Comprises 1,000 pure natural products extracted and purified from plants and microorganisms

AnalytiCon NATx: Includes 5,000 semi-synthetic natural products that were built based on natural product precursors with tractable chemistry

large blue instrument with a plate on top, large monitor screen and glassware on the bottom

Waters Preparative 2545 HPLC system

The Waters 2545 Quaternary Gradient Module (QGM) is a low-pressure mixing quaternary graident pump that serves as a solvent delivery device for AutoPurification Systems. Waters Fraction Collector III is an easy-to-use, standalone or software-controlled fraction collector.

large white instrument in the lab

Biotage Initiator+ Microwave Reactor

Efficient and controlled heating via microwave

Accelerated organic reactions 

Hetereocycles, cross-coupling reactions

Compound Libraries

Total collection: ~220,000 compounds

Diversity-Oriented Small Molecules

LOPAC 1280: Includes 1,280 known drugs and bioactives, covering all major target classes, including CPCRs and kinases

Microsource Spectrum: Comprises 2,400 US and international drugs, natural products and their derivatives, and reported bioactives (non-drug enzyme inhibitors, receptor blockers, membrane active compounds, and cellular toxins) that have not made it to clinical trials

AnalytiCon MEGx: Comprises 1,000 pure natural products extracted and purified from plants and microorganisms

AnalytiCon NATx: Includes 5,000 semi-synthetic natural products that were built based on natural product precursors with tractable chemistry

a blue and white instrument with large display monitor

Medicinal and Analytical Chemistry Labor and Instrument Internal Rates

Instrument Unit Internal Price
Molecule design, synthesis and analysis labor Per Hour $80
Molecule design, synthesis and analysis project Per Hour  $120 

Agilent 1290 LC - 6545 QTOF

Per Hour $75
Stuart Melting Point Meter Per Hour $25
Polarimeter Per Hour $25
Chemical Hood and Space Daily Per Chemist $25
Biotage Microwave Reactor Per Hour $40
Waters Preparative HPLC Per Hour $74
Buchi Evaporation System Per Hour $25
Biotage Flash Purification System Per Hour $71
Multichannel N2 Dryer  Per Hour  $25 

 

Note

  • Material cost for instrument usage will be charged separately if it occurs.

  • For instrument training and assisted instrument usage, labor rate will be added to the specific instrument rate.

  • Rates for external non-profit organizations and external profit organization are also available.

Please contact Lifan Zeng, PhD, for more information.